WEKO3
アイテム
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ユビキチンリガーゼ Cbl-bを介した筋萎縮の分子機構(Myo Lab)
https://jaxa.repo.nii.ac.jp/records/13223
https://jaxa.repo.nii.ac.jp/records/1322361e918ce-53b6-4f31-9dd9-bcb5e25a5ade
名前 / ファイル | ライセンス | アクション |
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64730076.pdf (911.3 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | ユビキチンリガーゼ Cbl-bを介した筋萎縮の分子機構(Myo Lab) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cbl-b ubiquitin ligase, skeletal muscle atrophy, IRS-1, Myo Lab | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Physiological relevance of Cbl-b ubiquitin ligase during microgravity- mediated muscle atrophy (Myo Lab) | |||||
著者 |
原田, 晃子
× 原田, 晃子× 河野, 尚平× 中尾, 玲子× 真板大野, 綾子× 平坂, 勝也× 奥村, 裕司× 鈴木, ひろみ× 嶋津, 徹× 山崎, 丘× 東端, 晃× 石岡, 憲昭× 二川, 健× HaradaSukeno, Akiko× Kohno, Shohei× Nakao, Reiko× Ohno, Ayako× Hirasaka, Katsuya× Okumura, Yuushi× Suzuki, Hiromi× Shimazu, Toru× Yamazaki, Takashi× Higashibata, Akira× Ishioka, Noriaki× Nikawa, Takeshi |
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著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野 | ||||||
著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野 | ||||||
著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野 | ||||||
著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野 | ||||||
著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野 | ||||||
著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野 | ||||||
著者所属 | ||||||
日本宇宙フォーラム宇宙利用事業部生命科学研究グループ | ||||||
著者所属 | ||||||
日本宇宙フォーラム | ||||||
著者所属 | ||||||
宇宙航空研究開発機構宇宙科学研究本部 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構宇宙科学研究本部ISS科学プロジェクト室 | ||||||
著者所属 | ||||||
徳島大学大学院ヘルスバイオサイエンス研究部 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School | ||||||
著者所属(英) | ||||||
en | ||||||
Life Science Research Group, Space Utilization Promotion Department,Japan Space Forum | ||||||
著者所属(英) | ||||||
en | ||||||
Life Science Research Group, Space Utilization Promotion Department,Japan Space Forum | ||||||
著者所属(英) | ||||||
en | ||||||
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
ISS Science Project Office, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS) | ||||||
著者所属(英) | ||||||
en | ||||||
Institute of Health Biosciences, the University of Tokushima Graduate School | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA) | |||||
書誌情報 |
宇宙利用シンポジウム en : Space Utilization Research: Proceedings of Space Utilization Symposium 巻 26, 発行日 2010-02 |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス) | |||||
会議概要(会議名, 開催地, 会期, 主催者等)(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan) | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Since human beings have been evolving technology of rocket, so that they can stay in space forseveral months and years. A long stay in space cause severe abnormalities in various organs. In particular, skeletal muscles are vulnerable to rapid and marked atrophy under microgravity. In the STS-90 mission, we previous report that the ubiquitin-dependent proteolytic pathway plays an important role in muscle atrophy. Expressly, we identified that Cbl-b (Casitus B-lineage lymphoma-b), ubiqutin ligase family (E3), plays a major role in skeletal muscle atrophy. Cbl-b deficient mice are resistant to muscle atrophy and dysfunction induced during unloading by tail-suspension. Here, we hypothesize that Cbl-b-dependent destruction of IRS-1(insulin receptor substrate-1) is a critical dual mediator of both increased protein degradation and reduced protein synthesis observed in muscle atrophy under microgravity. Next, we are planning to perform aspace experiment in "Kibo" to clarify the molecular mechanism of muscle atrophy caused by microgravity. In this paper, we report our history and future plan to develop space research (Myo Lab). | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 形態: カラー図版あり | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 共催: 日本学術会議 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 著者人数: 12人 | |||||
内容記述(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Physical characteristics: Original contains color illustrations | |||||
内容記述(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | joint hosting: The Science Council of Japan | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10324210 | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0064730076 |