View of gravity health science from molecular and cellular level focusing complimentary and alternative medical sciences: Proteins dynamics to make shape and their molecular chaperones in cultured myocyte
University of Tokyo Integrated Research System for Sustainability Science
University of Tokyo Integrated Research System for Sustainability Science
University of Tokyo Integrated Research System for Sustainability Science
University of Tokyo Graduate School of Arts and Sciences
Japan Aerospace Exploration Agency
Japan Aerospace Exploration Agency
Fukui University Graduate School of Engineering
University of Tokyo School of Engineering
National Institute of Health Sciences Division of Cellular and Gene Therapy Products
Tokyo University of Agriculture and Technology
出版者
宇宙航空研究開発機構宇宙科学研究本部
出版者（英）
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
雑誌名
宇宙利用シンポジウム 第24回 平成19年度
雑誌名(英)
Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium
ページ
302 - 303
発行年
2008-03
抄録（英）
Gravity is one of factors to maintain our living system to be active and healthy, because our biological system is constructed based on at least three important conditions under gravity on the earth as follows: (1) activity-dependent system at both levels of the cell and body, (2) morpho-dynamic system constituted of the cytoskeleton and extracellular matrix as, and (3) self organization to keep centering their mass at both levels of the cell and body. Such a system is organized by dynamically regulated protein filament system, such as actin, tubulin/MicroTubule (MT) and intermediate filament system. The use of filaments (the cytoskeleton, which is regulated with dynamic property) must be essential for maintaining shape responding own mobile activity intrinsic for especially animals under the gravity on the earth. Keeping such a morpho-dynamic system needs molecular chaperone, which takes care of free forms of proteins to keep equilibrium balancing free forms and filamentous forms, which has various functional properties of polarity, pushing ability, making various shapes and making fulcrum in the association with other protein complex at focal adhesion and extracellular matrix. Striated muscles are typical organized form that we can analyze a mechanism of two cytoskeleton systems of actin and tubulin/microtubule, because they work with balanced force each other under physiological condition against calcium oscillation per each beating. These organization of the cytoskeleton realizes autonomic beating like everlasting nonstop ping machine. It is interesting to study that what factors strongly relates to autonomous system, quantity of tension, and dynamic property. Studies to characterize tubulin/MT are rare in striated muscles. Beating heart expresses molecular chaperone alpha B-crystallin like as untigravitational muscle, which may support continuous beating keeping dynamic instability by taking care of chaperoning free forms of tubulin, actin and intermediate filament. Under space the expression levels of alpha B-crystallin may decrease because of the unloaded work performed by cardiac myocyte.
統合・代替医科学的問題と重力健康科学の展望:心筋細胞の形・ダイナミクスから考える
63706085.pdf
(333.63KB)
