WEKO3
アイテム
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In space environment, 0.2 to 1 mSv a day of space radiation exposure and micro gravity environment will affect body, tissue and cellular metabolisms. In this study, the effects of \u0027Low-dose Irradiation\u0027 and \u0027Micro gravity\u0027 on total gene expressions change were tested using two human neuron-like cell lines, NB-1 and SK-N-SH. The cells were treated with (1) 0.1 mGy X-irradiation, or (2) micro gravity environment for 24 hr, or (3) with 0.1 mGy X-irradiation and the microgravity for 24 hr. After the treatments, mRNA (messenger Ribonucleic Acid) was isolated from the cells and DNA (DeoxyriboNucleic Acid) expression was studied with DNA microarray analysis. The results showed that the gene categories with intensive expression change in all irradiated or microgravity exposed conditions were \u0027mitochondrial genome\u0027 (8/13; 61.5 percent) and \u0027ribosomal protein\u0027 (70/184; 38.0 percent), and the two were downregulated in every condition. 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宇宙線および微小重力による細胞内酸化ストレスの誘発
https://jaxa.repo.nii.ac.jp/records/13469
https://jaxa.repo.nii.ac.jp/records/13469150733d9-dc79-4c31-87cc-7c9343eb3986
名前 / ファイル | ライセンス | アクション |
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63706093.pdf (233.1 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | 宇宙線および微小重力による細胞内酸化ストレスの誘発 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | X線照射 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝子発現 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 宇宙線 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 微小重力 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | クリノスタット | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 酸化ストレス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ヒートショックタンパク質 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アルドラーゼB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ALDOB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | タンパク質 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 生物学的ストレス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | デオキシリボ核酸 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nerve cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | X-ray irradiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gene expression | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cosmic ray | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microgravity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | clinostat | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | oxidative stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | heat shock protein | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aldolase B | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ALDOB | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | protein | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | biological stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gene | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | deoxyribonucleic acid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Induction of intracellular oxidative stress by space radiation and microgravity | |||||
著者 |
馬嶋, 秀行
× 馬嶋, 秀行× 犬童, 寛子× 富田, 和男× 岩下, 洋一朗× 鈴木, ひろみ× 嶋津, 徹× 東端, 晃× 石岡, 憲昭× Majima, Hideyuki J.× Indo, Hiroko P.× Tomita, Kazuo× Iwashita, Yoichiro× Suzuki, Hiromi× Shimazu, Toru× Higashibata, Akira× Ishioka, Noriaki |
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著者所属 | ||||||
鹿児島大学 大学院医歯学総合研究科 | ||||||
著者所属 | ||||||
鹿児島大学 大学院医歯学総合研究科 | ||||||
著者所属 | ||||||
鹿児島大学 大学院医歯学総合研究科 | ||||||
著者所属 | ||||||
鹿児島大学 大学院医歯学総合研究科 | ||||||
著者所属 | ||||||
日本宇宙フォーラム 宇宙利用技術推進部 | ||||||
著者所属 | ||||||
日本宇宙フォーラム 宇宙利用技術推進部 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構 宇宙科学研究本部 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構 宇宙科学研究本部 | ||||||
著者所属(英) | ||||||
en | ||||||
Kagoshima University Graduate School of Medical and Dental Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
Kagoshima University Graduate School of Medical and Dental Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
Kagoshima University Graduate School of Medical and Dental Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
Kagoshima University Graduate School of Medical and Dental Sciences | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Space Forum Space Utilization Promotion Department | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Space Forum Space Utilization Promotion Department | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Aerospace Exploration Agency Institute of Space and Astronautical Science | ||||||
著者所属(英) | ||||||
en | ||||||
Japan Aerospace Exploration Agency Institute of Space and Astronautical Science | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS) | |||||
書誌情報 |
宇宙利用シンポジウム 第24回 平成19年度 en : Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium p. 331-332, 発行日 2008-03 |
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抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Long term manned space missions of International Space Station (ISS) is in progress, and a plan to explore Moon as well as to visit the Mars is also underway. In space environment, 0.2 to 1 mSv a day of space radiation exposure and micro gravity environment will affect body, tissue and cellular metabolisms. In this study, the effects of 'Low-dose Irradiation' and 'Micro gravity' on total gene expressions change were tested using two human neuron-like cell lines, NB-1 and SK-N-SH. The cells were treated with (1) 0.1 mGy X-irradiation, or (2) micro gravity environment for 24 hr, or (3) with 0.1 mGy X-irradiation and the microgravity for 24 hr. After the treatments, mRNA (messenger Ribonucleic Acid) was isolated from the cells and DNA (DeoxyriboNucleic Acid) expression was studied with DNA microarray analysis. The results showed that the gene categories with intensive expression change in all irradiated or microgravity exposed conditions were 'mitochondrial genome' (8/13; 61.5 percent) and 'ribosomal protein' (70/184; 38.0 percent), and the two were downregulated in every condition. The results also showed that up-regulated specific gene was only one in every condition, that was 'Small Nuclear RNA Activating Complex, Polypetide 5; SNAPC5, which activate RNA transcription. The individual genes that appeared intensively downregulated in every condition were 'forkhead box m1 (foxm1)', a gene for oxidative stress related transcription factor, 'HSPA8', a constitutive expressed heat shock protein 'ALDOB', a glycolysis gene. These results suggest that the space low-dose irradiation and micro gravity condition decrease newly production of protein, and may affect mitochondrial bio-energy production ability, and may induce intracellular oxidative stress. The results also suggest that 0.1 mGy irradiation and microgravity condition may decrease cellular anti-stress ability. | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0063706093 |