gravitational effect, synaptic plasticity, hippocampus, amygdala, synapse, electric stimulus, gravitational stimulus, long term potentiation, field potential
その他のタイトル（英）
Gravity change modulates synaptic plasticity in rat amygdala and hippocampus
Tokyo Medical and Dental University
Tokyo Medical and Dental University
Tokyo Medical and Dental University
Tokyo Medical and Dental University
Japan Women's University
Nagasaki University
Nagasaki University
Nagasaki University
出版者
宇宙航空研究開発機構宇宙科学研究本部
出版者（英）
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
雑誌名
宇宙利用シンポジウム 第21回 平成16年度
雑誌名(英)
Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium
ページ
225 - 227
発行年
2005-03
抄録（英）
The effects of 2 G hypergravity on the synaptic plasticity of hippocampus and amygdale were examined. After 5 min exposure to 2 G, rats were sacrificed and brain slices were prepared immediately. LTP (Long Term Potentiation) was analyzed by measuring the change in the amplitude of the negative deflection of field potential in hippocampus CA1 (Cornu Ammonis 1) and basolateral amygdala nucleus after tetanus stimulus of the Schaffer Collateral or entorhinal cortex, respectively. It was found that hypergravity significantly increased the efficiency of synaptic transmission in both hippocampus and amygdala. The synaptic plasticity in the limbic system might be a primarily sensitive response site to gravity change.
重力環境の変化とラット海馬および扁桃体におけるシナプス可塑性
