cell body size, hindlimb suspension, spinal motoneuron, tibialis anterior muscle, enzyme activity, rat, succinate dehydrogenase, musculus soleus, skeletal muscle, neuron
その他のタイトル（英）
Effects of hindlimb unloading on growth-related changes in cell body size and oxidative enzyme activity of spinal motoneurons innervating the rat tibialis anterior muscle
Kyoto University Graduate School of Human and Environmental Studies
Osaka University School of Health and Sport Sciences
Osaka University School of Health and Sport Sciences
Osaka University School of Health and Sport Sciences
出版者
宇宙航空研究開発機構宇宙科学研究本部
出版者（英）
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
雑誌名
宇宙利用シンポジウム 第21回 平成16年度
雑誌名(英)
Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium
ページ
231 - 233
発行年
2005-03
抄録（英）
Male rats were hindlimb-unloaded from postnatal day four to month three. The rats were sacrificed immediately, one, two, and three months after hindlimb reloading. Numbers, cell body sizes, and oxidative enzyme (succinate dehydrogenase) activities of spinal motoneurons innervating the fast tibialis anterior muscle were determined by quantitative enzyme histochemistry. The motoneurons innervating the tibialis anterior muscle were labeled by a retrograde neuronal tracer, nuclear yellow. No changes in number or oxidative enzyme activity of the motoneurons were observed after hindlimb unloading relative to the control level. However, the growth-related increase in cell body size of the motoneurons was inhibited by hindlimb unloading. The inhibited growth of cell body size of the motoneurons was normalized one month after hindlimb reloading. It is concluded that the increase in cell body size of the spinal motoneurons innervating the skeletal muscles during early postnatal growth was inhibited by hindlimb unloading and that the reloading-related recovery of cell body size is faster in the motoneurons innervating the fast skeletal muscle than in those innervating the slow skeletal muscle.
発育期の後肢懸垂がラットの前脛骨筋を神経支配する脊髄運動ニューロンの細胞体サイズと酸化系酵素活性に及ぼす影響
