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アイテム
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Hypergravity Provokes a Temporary Reduction in CD4+CD8+Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice
https://jaxa.repo.nii.ac.jp/records/22655
https://jaxa.repo.nii.ac.jp/records/226550f8e7fe3-65b3-4f48-9271-68973d3122c6
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-05-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Hypergravity Provokes a Temporary Reduction in CD4+CD8+Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
立石, 涼介
× 立石, 涼介× 秋山, 伸子× 宮内, 真紀× 良永, 理子× 笹沼, 寛樹× 工藤, 崇× 新保, 未来× 篠原, 正浩× 小畑, 孝二× 井上, 純一郎× 白川, 正輝× 芝, 大× 浅原, 弘嗣× 吉田, 進昭× 高橋, 智× 森田, 啓之× 秋山, 泰身× Tateishi, Ryosuke× Akiyama, Nobuko× Miyauchi, Maki× Yoshinaga, Riko× Sasanuma, Hiroki× Kudo, Takashi× Shimbo, Miki× Shinohara, Masahiro× Obata, Koji× Inoue, Junichiro× Shirakawa, Masaki× Shiba, Dai× Asahara, Hiroshi× Yoshida, Nobuaki× Takahashi, Satoru× Morita, Hironobu× Akiyama, Taishin |
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著者所属 | ||||||
東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属 | ||||||
東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属 | ||||||
東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属 | ||||||
東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA): 東京大学システム疾患モデル研究センター | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA): 筑波大学生命科学動物資源センター: | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA): 筑波大学生命科学動物資源センター: | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA): 東京医科歯科大学 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター: 岐阜大学大学院 | ||||||
著者所属 | ||||||
東京大学医科学研究所 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属 | ||||||
宇宙航空研究開発機構宇宙きぼう利用センター(JAXA): 東京医科歯科大学 | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA): 東京大学システム疾患モデル研究センター | ||||||
著者所属 | ||||||
宇宙航空研究開発機構きぼう利用センター(JAXA): 筑波大学生命科学動物資源センター: | ||||||
著者所属 | ||||||
宇宙航空研究開発機構宇宙きぼう利用センター(JAXA): 岐阜大学大学院 | ||||||
著者所属 | ||||||
東京大学医科学研究所: 宇宙航空研究開発機構きぼう利用センター(JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Center for Experimental Medicine and Systems Biology, The University of Tokyo | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Tokyo Medical and Dental University | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Gifu University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
The Institute of Medical Science, The University of Tokyo | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Tokyo Medical and Dental University | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba | ||||||
著者所属(英) | ||||||
en | ||||||
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Department of Physiology, Gifu University Graduate School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
The Institute of Medical Science, The University of Tokyo: Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA) | ||||||
出版者(英) | ||||||
出版者 | Public Library of Science | |||||
書誌情報 |
en : PLoS ONE 巻 10, 号 10, 発行日 2015-10-29 |
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抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Gravity change affects many immunological systems. We investigated the effects of hypergravity (2G) on murine thymic cells. Exposure of mice to 2G for three days reduced the frequency of CD4(+)CD8(+) thymocytes (DP) and mature medullary thymic epithelial cells (mTECs), accompanied by an increment of keratin-5 and keratin-8 double-positive (K5(+)K8(+)) TECs that reportedly contain TEC progenitors. Whereas the reduction of DP was recovered by a 14-day exposure to 2G, the reduction of mature mTECs and the increment of K5(+)K8(+) TEC persisted. Interestingly, a surgical lesion of the inner ear’s vestibular apparatus inhibited these hypergravity effects. Quantitative PCR analysis revealed that the gene expression of Aire and RANK that are critical for mTEC function and development were upregulated by the 3-day exposure and subsequently down-regulated by the 14-day exposure to 2G. Unexpectedly, this dynamic change in mTEC gene expression was independent of the vestibular apparatus. Overall, data suggest that 2G causes a temporary reduction of DP and a persistent reduction of mature mTECs in a vestibular system-dependent manner, and also dysregulates mTEC gene expression without involving the vestibular system. These data might provide insight on the impact of gravity change on thymic functions during spaceflight and living. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 形態: カラー図版あり | |||||
内容記述(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Physical characteristics: Original contains color illustrations | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1371/journal.pone.0141650 | |||||
関連名称 | info:doi/10.1371/journal.pone.0141650 | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: PA1610028000 |