Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba
University of Tsukuba
University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba
Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba: University of Tsukuba
Laboratory Animal Resource Center, University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Laboratory Animal Resource Center, University of Tsukuba
University of Tsukuba
University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba
University of Tsukuba: Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan
Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan
Graduate School of Life and Environmental Sciences, University of Tsukuba
University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA)
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Osaka University
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Gifu University Graduate School
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Tokyo Medical and Dental University
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): Tokyo Medical and Dental University
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): The University of Tokyo
The University of Tokyo
The University of Tokyo
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): The University of Tokyo
National Institute of Advanced Industrial Science and Technology (AIST): Sichuan Medical University
National Institute of Advanced Industrial Science and Technology (AIST)
University of Tsukuba: National Institute of Advanced Industrial Science and Technology (AIST)
University of Tsukuba: National Institute of Advanced Industrial Science and Technology (AIST)
University of Tsukuba: National Institute of Advanced Industrial Science and Technology (AIST)
National Institute of Advanced Industrial Science and Technology (AIST)
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba: National Institute of Advanced Industrial Science and Technology (AIST)
JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA)
JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA)
JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA)
National Center of Neurology and Psychiatry
National Center of Neurology and Psychiatry
Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA): University of Tsukuba: Laboratory Animal Resource Center, University of Tsukuba
出版者
日本実験動物学会
出版者（英）
Japanese Association for Laboratory Animal Science
雑誌名
Experimental Animals
巻
65
号
2
ページ
175 - 187
発行年
2016-01-28
抄録（英）
The Japan Aerospace Exploration Agency developed the mouse Habitat Cage Unit (HCU) for installation in the Cell Biology Experiment Facility (CBEF) onboard the Japanese Experimental Module (“Kibo”) on the International Space Station. The CBEF provides “space-based controls” by generating artificial gravity in the HCU through a centrifuge, enabling a comparison of the biological consequences of microgravity and artificial gravity of 1 g on mice housed in space. Therefore, prior to the space experiment, a ground-based study to validate the habitability of the HCU is necessary to conduct space experiments using the HCU in the CBEF. Here, we investigated the ground-based effect of a 32-day housing period in the HCU breadboard model on male mice in comparison with the control cage mice. Morphology of skeletal muscle, the thymus, heart, and kidney, and the sperm function showed no critical abnormalities between the control mice and HCU mice. Slight but significant changes caused by the HCU itself were observed, including decreased body weight, increased weights of the thymus and gastrocnemius, reduced thickness of cortical bone of the femur, and several gene expressions from 11 tissues. Results suggest that the HCU provides acceptable conditions for mouse phenotypic analysis using CBEF in space, as long as its characteristic features are considered. Thus, the HCU is a feasible device for future space experiments.
内容記述
形態: 図版あり
内容記述（英）
Full name: Takeda, Shinichi
Physical characteristics: Original contains illustrations
Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies
