gene expression, rat, microgravity, aerospace environment, manned space flight, long duration space flight, gravitational effect, hypergravity, C. elegans
その他のタイトル(英)
Biological influences of gravity environmental changes
JAXA Special Publication: FY2005 Research and Development Report on Neurophysiology Research Project at ISS Science Project Group
巻
JAXA-SP-05-040
ページ
5 - 7
発行年
2006-03-31
抄録
我々がこれまでに明らかにした、ラット過重力負荷時に前庭神経系で発現増加する遺伝子:CREB(Cyclic AMP-responsive element binding protein)、syntaxinについて、線虫ではどのような変化を起こしているかを検討したところ、哺乳類であるラットの結果とは相違を見せた。哺乳類と線虫の重力感知機構の違い(遺伝子発現の相違)や、異なる重力下にさらした期間の長さの違いが原因ではないかと考えられた。
抄録(英)
In this study, we compared the gene expression differences of CREB and syntaxin, which we found that were overexpressed under hypergravity in the rat vestibular end organs, in the Caenorhabditis elegans. The expression patterns of CREB and syntaxin were different from rat. It was thought that these results came from the differences of gravity perception mechanism and/or the differences of the period exposing to the hypergravity.