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重粒子線低密度照射による突然変異誘発効果の遺伝的不安定性の誘導
https://jaxa.repo.nii.ac.jp/records/13584
https://jaxa.repo.nii.ac.jp/records/13584f61a3c14-1491-4196-bdcd-ea2a47cbcf48
名前 / ファイル | ライセンス | アクション |
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63349086.pdf (312.0 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2015-03-26 | |||||
タイトル | ||||||
タイトル | 重粒子線低密度照射による突然変異誘発効果の遺伝的不安定性の誘導 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | イオンビーム | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 中性子ビーム | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放射線曝露 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝的不安定性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 繊維芽細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低流束照射 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 宇宙放射線 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放射線影響 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 生物学的影響 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 線形エネルギー転送 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 突然変異 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | バイスタンダー効果 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ion beam | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neutron beam | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | radiation exposure | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | genomic instability | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fibroblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | low- fluence radiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | space radiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | radiation effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | biological effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | linear energy transfer (LET) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mutation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bystander effect | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
その他のタイトル(英) | ||||||
その他のタイトル | Genomic instability in mutation induction induced by low-fluence particle radiations | |||||
著者 |
鈴木, 雅雄
× 鈴木, 雅雄× Suzuki, Masao |
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著者所属 | ||||||
放射線医学総合研究所 | ||||||
著者所属(英) | ||||||
en | ||||||
National Institute of Radiological Sciences | ||||||
出版者 | ||||||
出版者 | 宇宙航空研究開発機構宇宙科学研究本部 | |||||
出版者(英) | ||||||
出版者 | Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS) | |||||
書誌情報 |
宇宙利用シンポジウム 第23回 平成18年度 en : Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium p. 302-304, 発行日 2007-03 |
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抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We have studied biological effects in normal human fibroblasts induced by low-fluence high-LET (Linear Energy Transfer) ions to examine what kinds of radiation species induce genomic instability. Cells were pre-treated with low-fluence ions (approximately 1 milli-Gy/7 to 8 h) of either carbon or helium before following irradiation with X-ray challenging dose (1.5 Gy). There observed no difference in cell-killing effect in pre-treatment with either carbon or helium, when comparing to the pre-treatment with low-dose Cs-137 gamma rays. In mutation induction there was no difference in induced mutation frequency at 1.5 Gy of X-ray challenging dose between un-pretreated and gamma-ray pre-treated cells. On the other hand, it was around 4.0 times higher in carbon-ion pre-treated cells and 1.9 times higher in helium-ion pre-treated cells than in un-pretreated cells. There is evidence that genomic instability in mutation induction induced by the pre-treatment of low-fluence ions depends upon both LET and ion species. | |||||
資料番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 資料番号: AA0063349086 |