Osaka University Graduate School of Medicine
Osaka University Graduate School of Medicine
Osaka University Graduate School of Medicine
Osaka University Graduate School of Medicine
Osaka University Graduate School of Medicine
Osaka University Graduate School of Medicine
出版者
宇宙航空研究開発機構宇宙科学研究本部
出版者（英）
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
雑誌名
宇宙利用シンポジウム 第20回 平成15年度
雑誌名(英)
Space Utilization Research: Proceedings of the Twentieth Space Utilization Symposium
ページ
72 - 73
発行年
2004-03
抄録（英）
A Novel SCID technology is established for biomedical studies to evaluate the effect of space radiation on human organs and tissues. Morphology and function of human tissues were well maintained in the improved severe combined immunodeficient (SCID) mice for long period (2 to 3 years). Cs-137 ray exposure to transplant human thyroid tissues resulted in the disappearance of the follicles, significant decrease of human thyroid hormones, an increase of mutations, and change of gene expression, while low dose rate radiation exposure rarely induced these defects. Change of gene expression was also induced in extremely high incidence by fission neutron.
ヒト組織置換SCIDマウスを用いた宇宙放射線影響評価システムの開発
