{"created":"2023-06-20T14:45:38.682076+00:00","id":13101,"links":{},"metadata":{"_buckets":{"deposit":"80d56943-425d-41fc-91f7-031a95bf3359"},"_deposit":{"created_by":1,"id":"13101","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13101"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013101","sets":["1543:1633:1640","1887:1891"]},"author_link":["117142","117135","117140","117139","117136","117137","117141","117138"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Results of the experiment using \"Kibo\" module and its future development: Biological influences of space radiation"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"112","bibliographicPageStart":"111","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム: 第27回: 平成22年度"},{"bibliographic_title":"Space Utilization Research, Vol. 27 2011: Proceedings of The Twenty-seventh Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第27回宇宙利用シンポジウム (2011年1月24日-25日, 宇宙航空研究開発機構宇宙科学研究所相模原キャンパス), 相模原市, 神奈川県","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-seventh Space Utilization Symposium (January 24-25, 2011. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"An experiment was successfully conducted at \"Kibo\" module of International Space Station (ISS) from November 14, 2008 to March 28, 2009. In order to estimate the space-radiation effects, which were not influenced by other space environmental factors such as microgravity, frozen cells of human lymphoblastoid TK6 were brought to \"Kibo\" module and preserved there for134 days (total dose of 72 mSv). After recovery to Earth, we observed a ca.2.3-fold induction in thymidine kinase (TK) deficient mutation over the ground control. The indirect effects of space radiation were also detected by using the same frozen cell sample following the post-flight treatments such as 2 Gy X-ray irradiation or I-SceI digestion. The TK- mutation frequency after the X-ray irradiation was found to be ca.50% of the level of the X-ray irradiated ground control. The repair-efficiency for DNA double-strand break (I-sceI digestion) was ca.2-fold higher than the ground control case. These results suggest the possibility that frozen cells can record DNA damage accumulated during space flight and subsequently express the genetic and cellular responses when grown on earth. A part of the frozen cells were incubated under microG or 1 G in \"Kibo\" for 8 days. The post-flight assays demonstrated that cell-viability and mutability after the microG incubation were reduced to 55% and 59% of the level of 1G incubation, respectively. These results might suggest the possibility of microgravity influence in DNA repair, but future experiments are required for confirmation. An idea for the future experiment is also described here.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0065129041","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS)"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"国立医薬品食品衛生研究所"},{"subitem_text_value":"宇宙航空研究開発機構 (JAXA)"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research (RIKEN)"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research (RIKEN)"},{"subitem_text_language":"en","subitem_text_value":"National Institure of Health Sciences"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷田貝, 文夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戎崎, 俊一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本間, 正充"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatagai, Fumio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ebisuzaki, Tosikazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, Masamitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"65129041.pdf","filesize":[{"value":"259.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"65129041.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13101/files/65129041.pdf"},"version_id":"35b38c16-cd1e-41e4-85fc-2cf869077781"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"space radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microgravity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation induction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radioadaptive response","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"きぼう棟利用実験の成果と今後の展望: 宇宙放射線の生物影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"きぼう棟利用実験の成果と今後の展望: 宇宙放射線の生物影響"}]},"item_type_id":"5","owner":"1","path":["1640","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13101","relation_version_is_last":true,"title":["きぼう棟利用実験の成果と今後の展望: 宇宙放射線の生物影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:06:13.396384+00:00"}