{"created":"2023-06-20T14:45:39.078480+00:00","id":13107,"links":{},"metadata":{"_buckets":{"deposit":"4e905051-243c-49f8-89ae-a47d912b248b"},"_deposit":{"created_by":1,"id":"13107","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13107"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013107","sets":["1543:1633:1640","1887:1891"]},"author_link":["117227","117233","117246","117243","117228","117239","117232","117229","117235","117236","117241","117234","117240","117245","117231","117237","117238","117244","117242","117230"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Development of effective ingredient for muscle atrophy and News flash of Myolab cosmic experiment"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"128","bibliographicPageStart":"127","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム: 第27回: 平成22年度"},{"bibliographic_title":"Space Utilization Research, Vol. 27 2011: Proceedings of The Twenty-seventh Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第27回宇宙利用シンポジウム (2011年1月24日-25日, 宇宙航空研究開発機構宇宙科学研究所相模原キャンパス), 相模原市, 神奈川県","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-seventh Space Utilization Symposium (January 24-25, 2011. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"BACKGROUND: In muscle atrophy, Cbl-b ubiquitin ligase interacts with and degraded IGF-1 signaling intermediate IRS-1. This study aimed to inhibit Cbl-b-mediated IRS-1 ubiquitination and degradation by soy glycinin. METHODS: We used denervated mice fed soy glycinin diet, and examined the influence ofmuscle atrophy. RESULTS: Intake of soy glycinin prevented reduction of muscle wet weight and myofiber size. Furthermore, as a result in analysis of the effect to protection of IGF-1 pathway, the degradation and theubiquitination of IRS-1 were inhibited. In addition, elevation of gene expression of MAFbx/atrogin-1 and MuRF-1, activated by the loss of IRS-1, decresed significantly. CONCLUSIONS: This study suggested that soy glycinin protein contains inhibitory peptides against Cbl-b ubiqutin ligase. Soy glycinin peptide may provide new therapeutic applications for the prevention or treatment of muscle atrophy.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"著者人数: 12人","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Number of authors: 12","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0065129047","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS)"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"宇宙航空研究開発機構有人宇宙環境利用ミッション本部宇宙医学生物学研究室 (JAXA)"},{"subitem_text_value":"宇宙航空研究開発機構 (JAXA)"},{"subitem_text_value":"テキサス大学オースチン校"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"JAXA Space Biomedical Research Office, Human Space Systems and Utilization Mission Directorate, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"University of Texas, Austin"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上村, 啓太"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山, 智成"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"越智, ありさ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河野, 尚平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中尾, 玲子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平坂, 勝也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"真板, 綾子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 晃子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥村, 裕司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanmura, Keita","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yama, Tomonari","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ochi, Arisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirasaka, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maita, Ayako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Yuushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"65129047.pdf","filesize":[{"value":"300.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"65129047.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13107/files/65129047.pdf"},"version_id":"a147aa8d-61a7-4260-a2fc-716ae74c5d77"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cbl-b","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Denervation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Soy glycinin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ubiquitin-dependent proteolysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"廃用性筋萎縮に有効な食材の開発とMyolab宇宙実験の速報","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"廃用性筋萎縮に有効な食材の開発とMyolab宇宙実験の速報"}]},"item_type_id":"5","owner":"1","path":["1640","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13107","relation_version_is_last":true,"title":["廃用性筋萎縮に有効な食材の開発とMyolab宇宙実験の速報"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:06:02.690386+00:00"}