@inproceedings{oai:jaxa.repo.nii.ac.jp:00013132,
 author = {本田, 陽子 and 東端, 晃 and 石岡, 憲昭 and 東谷, 篤志 and 福井, 啓二 and 田中, 雅嗣 and 本田, 修二 and Honda, Yoko and Higashibata, Akira and Ishioka, Noriaki and Higashitani, Atsushi and Fukui, Keiji and Tanaka, Masashi and Honda, Shuji},
 book = {宇宙利用シンポジウム: 第27回: 平成22年度, Space Utilization Research, Vol. 27 2011: Proceedings of The Twenty-seventh Space Utilization Symposium},
 month = {Mar},
 note = {第27回宇宙利用シンポジウム (2011年1月24日-25日, 宇宙航空研究開発機構宇宙科学研究所相模原キャンパス), 相模原市, 神奈川県, The Twenty-seventh Space Utilization Symposium (January 24-25, 2011. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, To clarify the effects of the space environment on the aging rate of organisms, we are preparing the study of nematode Caenorhabditis elegans in space as a model. We have investigated the effects of a 10-day space flight on an aging marker in the International C. elegans Experiment (ICE)-First, 2004. We examined the change in the polyglutamine (polyQ) aggregation in the transgenic C. elegans of (CAG)35 with yellow fluorescent protein under muscle myosin heavy chain promoter. The polyQ aggregation in space-flown worms was less than that in the ground control ones. We compared the gene expression levels between the ground control worms and the space-flown worms. Some nerve specific genes were down regulated in space-flown worms. We also examined the effects of the inactivation of these genes on lifespan of C. elegans. We found that the RNAi and/or mutation of each of the 7 genes extended the lifespan. These findings suggest that the aging rate of the space-flown nematodes may be slower than that of the ground control ones. We propose that the further study of aging of C. elegans in space. We also propose the other aging marker for the space experiment of C. elegans., 資料番号: AA0065129072},
 pages = {195--196},
 publisher = {宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS), Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)},
 title = {宇宙環境における線虫の老化: WG平成22年度活動報告},
 volume = {27},
 year = {2011}
}