@inproceedings{oai:jaxa.repo.nii.ac.jp:00013134,
 author = {柳澤, 誠 and 古野, 伸明 and 渡部, 稔 and 柏木, 啓子 and 花田, 秀樹 and 新海, 正 and 吉留, 賢 and 久保, 英夫 and 坂井, 雅夫 and 藤井, 博匡 and 鈴木, 賢一 and 山下, 雅道 and Yanagisawa, Makoto and Furuno, Nobuaki and Watanabe, Minoru and Kashiwagi, Keiko and Hanada, Hideki and Shinkai, Tadashi and Yoshitome, Satoshi and Kubo, Hideo and Sakai, Masao and Fujii, Hirotada and Suzuki, Kenichi and Yamashita, Masamichi},
 book = {宇宙利用シンポジウム: 第27回: 平成22年度, Space Utilization Research, Vol. 27 2011: Proceedings of The Twenty-seventh Space Utilization Symposium},
 month = {Mar},
 note = {第27回宇宙利用シンポジウム (2011年1月24日-25日, 宇宙航空研究開発機構宇宙科学研究所相模原キャンパス), 相模原市, 神奈川県, The Twenty-seventh Space Utilization Symposium (January 24-25, 2011. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, Previously we showed that amphibian embryos raised under hypergravity conditions develop the various abnormalities, including head-defects such as microcephaly and cyclopia as the most common. We also showed that the expression of Xag (cement grand marker), and Xotx2 (involved in fore- and midbrain and eye development) are suppressed in embryos under hypergravity. However, it is not known which region of the head is most sensitive to hypergravity, and if all regions of the head are affected by hypergravity. In the present study we investigated the effects of hypergravity on gene expression of Xag, Xotx2 and En2 (expressed in the region between midbrain and hindbrain) in tail-bud embryos of Xenopua laevis by wholemount in situ hybridization (WISH). Double staining with Xag and Xotx2 revealed that Xotx2 expression was suppressed in embryos exposed to 5G, although the region expressed Xag was not changed. Furthermore, En2 expression was not affected. These results strongly suggest that development of eye and fore- and midbrain is most sensitive to hypergavity and hypergravity does not affect the region posterior to the hindbrain., 著者人数: 13人, Number of authors: 13, 資料番号: AA0065129074},
 pages = {198--200},
 publisher = {宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS), Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)},
 title = {過重力によって生じたアフリカツメガエル初期胚の頭部形成異常の解析 II},
 volume = {27},
 year = {2011}
}