{"created":"2023-06-20T14:45:40.671082+00:00","id":13134,"links":{},"metadata":{"_buckets":{"deposit":"0f7d2060-1bf7-4f64-b5a4-86002b0423db"},"_deposit":{"created_by":1,"id":"13134","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13134"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013134","sets":["1543:1633:1640","1887:1891"]},"author_link":["117702","117705","117713","117701","117707","117693","117712","117691","117699","117703","117708","117695","117697","117694","117700","117710","117709","117706","117698","117714","117696","117692","117704","117711"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Molecular analysis of the head-defects in the Xenopus embryos raised hypergravity condition. II"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"200","bibliographicPageStart":"198","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム: 第27回: 平成22年度"},{"bibliographic_title":"Space Utilization Research, Vol. 27 2011: Proceedings of The Twenty-seventh Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第27回宇宙利用シンポジウム (2011年1月24日-25日, 宇宙航空研究開発機構宇宙科学研究所相模原キャンパス), 相模原市, 神奈川県","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-seventh Space Utilization Symposium (January 24-25, 2011. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Previously we showed that amphibian embryos raised under hypergravity conditions develop the various abnormalities, including head-defects such as microcephaly and cyclopia as the most common. We also showed that the expression of Xag (cement grand marker), and Xotx2 (involved in fore- and midbrain and eye development) are suppressed in embryos under hypergravity. However, it is not known which region of the head is most sensitive to hypergravity, and if all regions of the head are affected by hypergravity. In the present study we investigated the effects of hypergravity on gene expression of Xag, Xotx2 and En2 (expressed in the region between midbrain and hindbrain) in tail-bud embryos of Xenopua laevis by wholemount in situ hybridization (WISH). Double staining with Xag and Xotx2 revealed that Xotx2 expression was suppressed in embryos exposed to 5G, although the region expressed Xag was not changed. Furthermore, En2 expression was not affected. These results strongly suggest that development of eye and fore- and midbrain is most sensitive to hypergavity and hypergravity does not affect the region posterior to the hindbrain.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"著者人数: 13人","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Number of authors: 13","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0065129074","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS)"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"徳島大学総合科学部"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"東京都老人総合研究所レドックス制御研究グループ"},{"subitem_text_value":"鳥取大学医学部生命科学科"},{"subitem_text_value":"東京都臨床医学総合研究所神経生物学部門"},{"subitem_text_value":"鹿児島大学理学部"},{"subitem_text_value":"札幌医科大学保健医療学部"},{"subitem_text_value":"愛媛大学沿岸環境科学研究センター"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS)"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Integrated Arts and Sciences, University of Tokushima"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian Biology, Graduate School Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian Biology, Graduate School Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"School of Life Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurobiology, Tokyo Metropolitan Institute of Medical Science"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Science, Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"School of Health Science, Sapporo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Center for Marine Environmental Studies, Ehime University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柳澤, 誠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"古野, 伸明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡部, 稔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柏木, 啓子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"花田, 秀樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"新海, 正"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉留, 賢"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久保, 英夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂井, 雅夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤井, 博匡"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 賢一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山下, 雅道"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagisawa, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuno, Nobuaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Minoru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashiwagi, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shinkai, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshitome, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Hideo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Hirotada","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kenichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Masamichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"65129074.pdf","filesize":[{"value":"897.0 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