{"created":"2023-06-20T14:45:40.858982+00:00","id":13138,"links":{},"metadata":{"_buckets":{"deposit":"1158325d-2d6a-40c7-9b47-b57d048d48e3"},"_deposit":{"created_by":1,"id":"13138","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13138"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013138","sets":["1543:1633:1640","1887:1891"]},"author_link":["117778","117780","117785","117779","117784","117777","117782","117781","117776","117783","117786","117775"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Detrimental effects of microgravity on mouse preimplantation development in vitro"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"208","bibliographicPageStart":"207","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム: 第27回: 平成22年度"},{"bibliographic_title":"Space Utilization Research, Vol. 27 2011: Proceedings of The Twenty-seventh Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第27回宇宙利用シンポジウム (2011年1月24日-25日, 宇宙航空研究開発機構宇宙科学研究所相模原キャンパス), 相模原市, 神奈川県","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-seventh Space Utilization Symposium (January 24-25, 2011. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Sustaining life beyond Earth either on space stations or on other planets will require a clear understanding of how the space environment affects key phases of mammalian reproduction. However, because of the difficulty of doing such experiments in mammals, most studies of reproduction in space have been carried out with other taxa, such as sea urchins, fish, amphibians or birds. Here, we studied the possibility of mammalian fertilization and preimplantation development under microgravity (microG) conditions using a three-dimensional (3D) clinostat, which faithfully simulates 10(-3) G using 3D rotation. Fertilization occurred normally in vitro under microG. However, although we obtained 75 healthy offspring from microG-fertilized and -cultured embryos after transfer to recipient females, the birth rate was lower than among the 1G controls. Immunostaining demonstrated that in vitro culture under microG caused slower development and fewer trophectoderm cells than in 1G controls but did not affect polarization of the blastocyst. These results suggest for the first time that fertilization can occur normally under microG environment in a mammal, but normal preimplantation embryo development might require 1G.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0065129078","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS)"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"理化学研究所発生・再生科学総合研究センター"},{"subitem_text_value":"広島大学大学院保健学研究科"},{"subitem_text_value":"理化学研究所発生・再生科学総合研究センター"},{"subitem_text_value":"理化学研究所発生・再生科学総合研究センター"},{"subitem_text_value":"広島大学大学院保健学研究科"},{"subitem_text_value":"理化学研究所発生・再生科学総合研究センター"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory for Genomic Reprogramming, Institute of Physical and Chemical Research (RIKEN)"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Health Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory for Genomic Reprogramming, Institute of Physical and Chemical Research (RIKEN)"},{"subitem_text_language":"en","subitem_text_value":"Laboratory for Genomic Reprogramming, Institute of Physical and Chemical Research (RIKEN)"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Health Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory for Genomic Reprogramming, Institute of Physical and Chemical Research (RIKEN)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"若山, 清香"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河原, 裕美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"李, 羽中"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山縣, 一夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"弓削, 類"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"若山, 照彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakayama, Sayaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawahara, Yumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, C","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamagata, Kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yuge, Louis","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakayama, Teruhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"65129078.pdf","filesize":[{"value":"214.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"65129078.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13138/files/65129078.pdf"},"version_id":"7e49e5da-ba2e-47ad-a94c-b2456d7463a9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"マウス初期胚の発生における微小重力の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス初期胚の発生における微小重力の影響"}]},"item_type_id":"5","owner":"1","path":["1640","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13138","relation_version_is_last":true,"title":["マウス初期胚の発生における微小重力の影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:05:05.420282+00:00"}