@inproceedings{oai:jaxa.repo.nii.ac.jp:00013221,
 author = {本田, 陽子 and 東端, 晃 and 石岡, 憲昭 and 田中, 雅嗣 and 本田, 修二 and Honda, Yoko and Higashibata, Akira and Ishioka, Noriaki and Tanaka, Masashi and Honda, Shuji},
 book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium},
 month = {Feb},
 note = {第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan), To clarify the effects of the space environment on the aging rate of organisms, we proposed the study of nematode Caenorhabditis elegans in space as a model. We have investigated the effects of a 10-day space flight on an aging marker in the International C. elegans Experiment (ICE)-First, 2004. We examined the change in the polyglutamine (polyQ) aggregation in the transgenic C. elegans of (CAG)35 with yellow fluorescent protein under muscle myosin heavy chain promoter. The polyQ aggregation in space-flown organisms was less than that in the ground control ones. We compared the gene expression levels between the ground control worms and the space-flown worms. Some nerve specific genes were down regulated in space-flown worms. We also examined the effects of the inactivation of these genes on lifespan of C. elegans. We found that the RNAi of each of the 5 genes extended the lifespan. These findings suggest that the aging rate of the space-flown nematodes may be slower than that of the ground control ones. We propose that the further study of aging of C. elegans in space., 共催: 日本学術会議, joint hosting: The Science Council of Japan, 資料番号: AA0064730074},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)},
 title = {宇宙空間における線虫の老化},
 volume = {26},
 year = {2010}
}