{"created":"2023-06-20T14:45:44.628783+00:00","id":13221,"links":{},"metadata":{"_buckets":{"deposit":"8f1f630d-389d-42f5-85e3-988c168d03e0"},"_deposit":{"created_by":1,"id":"13221","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13221"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013221","sets":["1543:1633:1641","1887:1891"]},"author_link":["119337","119331","119332","119338","119333","119340","119334","119339","119336","119335"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Study of the effects of space flight on the aging of C. elegans"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"To clarify the effects of the space environment on the aging rate of organisms, we proposed the study of nematode Caenorhabditis elegans in space as a model. We have investigated the effects of a 10-day space flight on an aging marker in the International C. elegans Experiment (ICE)-First, 2004. We examined the change in the polyglutamine (polyQ) aggregation in the transgenic C. elegans of (CAG)35 with yellow fluorescent protein under muscle myosin heavy chain promoter. The polyQ aggregation in space-flown organisms was less than that in the ground control ones. We compared the gene expression levels between the ground control worms and the space-flown worms. Some nerve specific genes were down regulated in space-flown worms. We also examined the effects of the inactivation of these genes on lifespan of C. elegans. We found that the RNAi of each of the 5 genes extended the lifespan. These findings suggest that the aging rate of the space-flown nematodes may be slower than that of the ground control ones. We propose that the further study of aging of C. elegans in space.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"共催: 日本学術会議","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"joint hosting: The Science Council of Japan","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064730074","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京都健康長寿医療センター研究所"},{"subitem_text_value":"宇宙航空研究開発機構"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部ISS科学プロジェクト室"},{"subitem_text_value":"東京都健康長寿医療センター研究所"},{"subitem_text_value":"東京都健康長寿医療センター研究所"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"ISS Science Project Office, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本田, 陽子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 雅嗣"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本田, 修二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64730074.pdf","filesize":[{"value":"416.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64730074.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13221/files/64730074.pdf"},"version_id":"01e1e8f2-3225-4c14-a097-d5f4bfce293b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"宇宙空間における線虫の老化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"宇宙空間における線虫の老化"}]},"item_type_id":"5","owner":"1","path":["1641","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13221","relation_version_is_last":true,"title":["宇宙空間における線虫の老化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:02:28.060018+00:00"}