@inproceedings{oai:jaxa.repo.nii.ac.jp:00013223,
 author = {原田, 晃子 and 河野, 尚平 and 中尾, 玲子 and 真板大野, 綾子 and 平坂, 勝也 and 奥村, 裕司 and 鈴木, ひろみ and 嶋津, 徹 and 山崎, 丘 and 東端, 晃 and 石岡, 憲昭 and 二川, 健 and HaradaSukeno, Akiko and Kohno, Shohei and Nakao, Reiko and Ohno, Ayako and Hirasaka, Katsuya and Okumura, Yuushi and Suzuki, Hiromi and Shimazu, Toru and Yamazaki, Takashi and Higashibata, Akira and Ishioka, Noriaki and Nikawa, Takeshi},
 book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium},
 month = {Feb},
 note = {第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan), Since human beings have been evolving technology of rocket, so that they can stay in space forseveral months and years. A long stay in space cause severe abnormalities in various organs. In particular, skeletal muscles are vulnerable to rapid and marked atrophy under microgravity. In the STS-90 mission, we previous report that the ubiquitin-dependent proteolytic pathway plays an important role in muscle atrophy. Expressly, we identified that Cbl-b (Casitus B-lineage lymphoma-b), ubiqutin ligase family (E3), plays a major role in skeletal muscle atrophy. Cbl-b deficient mice are resistant to muscle atrophy and dysfunction induced during unloading by tail-suspension. Here, we hypothesize that Cbl-b-dependent destruction of IRS-1(insulin receptor substrate-1) is a critical dual mediator of both increased protein degradation and reduced protein synthesis observed in muscle atrophy under microgravity. Next, we are planning to perform aspace experiment in "Kibo" to clarify the molecular mechanism of muscle atrophy caused by microgravity. In this paper, we report our history and future plan to develop space research (Myo Lab)., 形態: カラー図版あり, 共催: 日本学術会議, 著者人数: 12人, Physical characteristics: Original contains color illustrations, joint hosting: The Science Council of Japan, 資料番号: AA0064730076},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)},
 title = {ユビキチンリガーゼ Cbl-bを介した筋萎縮の分子機構(Myo Lab)},
 volume = {26},
 year = {2010}
}