{"created":"2023-06-20T14:45:44.717554+00:00","id":13223,"links":{},"metadata":{"_buckets":{"deposit":"c409b0bf-598b-4e5b-be27-81dc6e0b2b9a"},"_deposit":{"created_by":1,"id":"13223","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13223"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013223","sets":["1543:1633:1641","1887:1891"]},"author_link":["119387","119398","119402","119403","119393","119390","119394","119386","119405","119383","119389","119388","119385","119395","119400","119401","119399","119397","119406","119404","119396","119384","119392","119391"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Physiological relevance of Cbl-b ubiquitin ligase during microgravity- mediated muscle atrophy (Myo Lab)"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Since human beings have been evolving technology of rocket, so that they can stay in space forseveral months and years. A long stay in space cause severe abnormalities in various organs. In particular, skeletal muscles are vulnerable to rapid and marked atrophy under microgravity. In the STS-90 mission, we previous report that the ubiquitin-dependent proteolytic pathway plays an important role in muscle atrophy. Expressly, we identified that Cbl-b (Casitus B-lineage lymphoma-b), ubiqutin ligase family (E3), plays a major role in skeletal muscle atrophy. Cbl-b deficient mice are resistant to muscle atrophy and dysfunction induced during unloading by tail-suspension. Here, we hypothesize that Cbl-b-dependent destruction of IRS-1(insulin receptor substrate-1) is a critical dual mediator of both increased protein degradation and reduced protein synthesis observed in muscle atrophy under microgravity. Next, we are planning to perform aspace experiment in \"Kibo\" to clarify the molecular mechanism of muscle atrophy caused by microgravity. In this paper, we report our history and future plan to develop space research (Myo Lab).","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"},{"subitem_description":"共催: 日本学術会議","subitem_description_type":"Other"},{"subitem_description":"著者人数: 12人","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"Physical characteristics: Original contains color illustrations","subitem_description_type":"Other"},{"subitem_description":"joint hosting: The Science Council of Japan","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064730076","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部栄養医科学講座生体栄養学分野"},{"subitem_text_value":"日本宇宙フォーラム宇宙利用事業部生命科学研究グループ"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部"},{"subitem_text_value":"宇宙航空研究開発機構"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部ISS科学プロジェクト室"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Physiology, Institute of Health Biosciences, The University ofTokushima Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Life Science Research Group, Space Utilization Promotion Department,Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Life Science Research Group, Space Utilization Promotion Department,Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"ISS Science Project Office, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"},{"subitem_text_language":"en","subitem_text_value":"Institute of Health Biosciences, the University of Tokushima Graduate School"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原田, 晃子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河野, 尚平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中尾, 玲子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"真板大野, 綾子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平坂, 勝也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥村, 裕司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, ひろみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"嶋津, 徹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山崎, 丘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"二川, 健"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HaradaSukeno, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohno, Ayako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirasaka, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Yuushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimazu, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamazaki, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nikawa, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64730076.pdf","filesize":[{"value":"911.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64730076.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13223/files/64730076.pdf"},"version_id":"c328d822-c557-48dc-b46f-a5114770173b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cbl-b ubiquitin ligase, skeletal muscle atrophy, IRS-1, Myo Lab","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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