{"created":"2023-06-20T14:45:45.342540+00:00","id":13237,"links":{},"metadata":{"_buckets":{"deposit":"8d2ffac2-c61f-4522-9919-dd715d6b8fa5"},"_deposit":{"created_by":1,"id":"13237","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13237"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013237","sets":["1543:1633:1641","1887:1891"]},"author_link":["119683","119673","119672","119675","119676","119677","119684","119674","119678","119679","119680","119682","119671","119681"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Space experiment \"Rad Gene\" at Kibo-report 1: p53-Dependent geneexpression in human cultured cells after spaceflight in a frozen state"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"A p53 tumor suppressor protein is generally thought to contribute to the genetic stability of cells against DNA damage through the activity of p53-centered signal transduction pathways. To clarify the effect of the space radiations on the gene expression of p53-dependent regulated genes, space experiments were performed with two human cultured lymphoblastoid cell lines: one cells line (TSCE5) bears a wild-type p53 gene status, and another cells line (WTK1) bears a mutated p53 gene status. Frozen human lymphoblastoid cells were stored on the International Space Station (ISS) for 133 days. The gene expression was analyzed by using DNA chip (a 44k whole human genome microarray, Agilent Technologies Inc.) after culturing the space samples for 6 h on the ground after their return from space. p53-Dependent up-regulated gene expression was found for 50 genes and p53-dependent down-regulated gene expression was found for 94 genes. The biological meanings of them were discussed from an aspect of the gene function about up- and down-regulated genes by the exposure of space radiations at low doses.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"共催: 日本学術会議","subitem_description_type":"Other"}]},"item_5_description_19":{"attribute_name":"内容記述（英）","attribute_value_mlt":[{"subitem_description":"joint hosting: The Science Council of Japan","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064730090","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"奈良県立医科大学 : 宇宙航空研究開発機構"},{"subitem_text_value":"奈良県立医科大学 : 宇宙航空研究開発機構"},{"subitem_text_value":"宇宙航空研究開発機構 : 日本宇宙フォーラム宇宙利用事業部生命科学研究グループ"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"鹿児島大学 : エイ・イー・エス"},{"subitem_text_value":"鹿児島大学 : エイ・イー・エス"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部ISS科学プロジェクト室 : 鹿児島大学"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Nara Medical University : Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Nara Medical University : Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA) : Life Science Research Group, Space Utilization Promotion Department,Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Life Science Research Group, Space Utilization Promotion Department,Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Kagoshima University : Advanced Engineering Services (AES)"},{"subitem_text_language":"en","subitem_text_value":"Kagoshima University : Advanced Engineering Services (AES)"},{"subitem_text_language":"en","subitem_text_value":"ISS Science Project Office, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS) : Kagoshima University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 昭久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大西, 武雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, ひろみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"嶋津, 徹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"関, 真也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋爪, 藤子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Akihisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onishi, Takeo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimazu, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seki, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashizume, Toko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64730090.pdf","filesize":[{"value":"667.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64730090.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13237/files/64730090.pdf"},"version_id":"0405fa18-10b0-4757-aed5-abc2080838ba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"International Space Station, space radiations, p53, gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"「きぼう」でのRad Gene 宇宙実験報告1 : ヒト培養系における宇宙飛行後のp53 依存性遺伝子発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"「きぼう」でのRad Gene 宇宙実験報告1 : ヒト培養系における宇宙飛行後のp53 依存性遺伝子発現"}]},"item_type_id":"5","owner":"1","path":["1641","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13237","relation_version_is_last":true,"title":["「きぼう」でのRad Gene 宇宙実験報告1 : ヒト培養系における宇宙飛行後のp53 依存性遺伝子発現"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:01:57.901984+00:00"}