{"created":"2023-06-20T14:45:46.268621+00:00","id":13258,"links":{},"metadata":{"_buckets":{"deposit":"0d5623d0-d3ce-4a38-8ee1-c085710ad129"},"_deposit":{"created_by":1,"id":"13258","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13258"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013258","sets":["1543:1633:1642","1887:1891"]},"author_link":["120017","120021","120018","120019","120022","120035","120028","120033","120024","120034","120029","120026","120031","120032","120023","120025","120020","120016","120027","120030"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Gene expression profiles of human neuron-like cells exposed to cosmic rays"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Long term manned space missions are planned to implement within the first two decades of the 21st century. A mission of International Space Station (ISS) is in progress, and a plan to explore Moon as well as to visit the Mars is also underway. In space field, the plan will allow space man to live for long terms to do experiments to examine various space sciences. In space environment, 0.2 - 0.3 mSv a day of radiation exposure will affect cellular metabolisms. As such missions will inevitably result in a significant space radiation exposure on the astronauts, there is an increasing demand to examine their risk. Evaluation of realistic risk associated with the space mission will be in urgent demand to protect them adequately based on both physical and biological knowledge. Considering cellular metabolisms or homeostasis, which affect their risk, examinations of gene expression change would be important. In this study, a human neuron-like cell line, NB-1 was irradiated with 0.1 mGy, 1.0 mGy, 10 mGy, and 100 mGy in single exposure. Thirty minutes and 2 hours after the treatments, mRNA was isolated from the cells and gene expressions were studied with Quantitative PCR analysis. The results showed that the both up- and downregulated gene expressions were seen among mitochondrial genome, electron transport and TCA cycle genes. On the other hand, beta-oxidation, ion transport, ATP production, antioxidative enzymes and factors related gene expressions were downregulated. DNA repair, glycolysis, heat shock protein, and apoptosis related gene expressions were also downregulated except for some genes such as p53. The autophagy related gene, and necrosis related gene expressions were also downregulated. These results suggest that the space low-dose irradiation induce intracellular oxidative stress, and may decrease at least partial apoptosis-related gene expression changes, i.e., may increase potential risk of cancer or neuro-degenerative diseases.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"著者人数: 11人","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064297014","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"鹿児島大学大学院医歯学総合研究科"},{"subitem_text_value":"鹿児島大学大学院医歯学総合研究科"},{"subitem_text_value":"鹿児島大学大学院医歯学総合研究科"},{"subitem_text_value":"鹿児島大学大学院医歯学総合研究科"},{"subitem_text_value":"日本宇宙フォーラム宇宙利用事業部生命科学研究グループ"},{"subitem_text_value":"日本宇宙フォーラム宇宙利用事業部生命科学研究グループ"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部宇宙環境利用科学研究系宇宙生命科学"},{"subitem_text_value":"宇宙航空研究開発機構宇宙医学グループ"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部宇宙環境利用科学研究系宇宙生命科学"},{"subitem_text_value":"有人宇宙システム"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical and Dental Sciences, Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical and Dental Sciences, Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical and Dental Sciences, Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical and Dental Sciences, Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"Life Science Research Group, Space Utilization Promotion Department, Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Life Science Research Group, Space Utilization Promotion Department, Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Department of Space Biology and Microgravity Sciences, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Space Medicine Group, Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Department of Space Biology and Microgravity Sciences, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Manned Space Systems"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"馬嶋, 秀行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"犬童, 寛子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"富田, 和男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩下, 洋一朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, ひろみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"嶋津, 徹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"泉, 龍太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"桝田, 大輔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Majima, Hideyuki J","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Indo, Hiroko P","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwashita, Yoichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimazu, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumi, Ryutaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64297014.pdf","filesize":[{"value":"683.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64297014.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13258/files/64297014.pdf"},"version_id":"9dcd3f74-fe88-47bb-a842-5a3d46eb5f67"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"宇宙線によるヒト神経細胞遺伝子の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"宇宙線によるヒト神経細胞遺伝子の発現"}]},"item_type_id":"5","owner":"1","path":["1642","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13258","relation_version_is_last":true,"title":["宇宙線によるヒト神経細胞遺伝子の発現"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:01:17.904504+00:00"}