@inproceedings{oai:jaxa.repo.nii.ac.jp:00013260,
 author = {野村, 大成 and 梁, 治子 and 足立, 成基 and 中島, 裕夫 and 本行, 忠志 and 藤川, 和男 and 伊藤, 哲夫 and 松塚, 文夫 and Nomura, Taisei and Ryo, Haruko and Adachi, Shigeki and Nakajima, Hiroo and Hongyo, Tadashi and Fujikawa, Kazuo and Itoh, Tetsuo and Matsuzuka, Fumio},
 book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium},
 month = {Mar},
 note = {第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), To study the risk of cosmic radiation, two projects, effects on human organs and tissues maintained in super-SCID mice and transgenerational effects in the offspring of mice exposed to radiation were carried out;. Morphological and functional (hormone secretion) changes and/or mutations were induced in human thyroid tissues by high doses and high dose rate of X- and gamma-rays (9-33 Gy) and reactor neutron (0.2 Gy x 6), but not by same doses with low dose-rate of gamma-rays, showing apparent dose rate effects in human thyroid tissues. Neutron (0.2 Gy x 4) induced bigger changes in gene expression than 2 Gy of gamma-rays, suggesting high RBE of neutron. Microsatellite mutations and lymphocytic leukemia were induced dose-dependently in the offspring of N5 male mice exposed to 0.2 and 0.4 Gy of neutron. The incidence was 10 folds higher than our former X-ray and gamma-ray studies, again suggesting high RBE., 形態: カラー図版あり, 資料番号: AA0064297016},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)},
 title = {ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価},
 volume = {25},
 year = {2009}
}