{"created":"2023-06-20T14:45:46.356863+00:00","id":13260,"links":{},"metadata":{"_buckets":{"deposit":"833b1080-9f3b-4112-b7af-03082c0e5dcc"},"_deposit":{"created_by":1,"id":"13260","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13260"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013260","sets":["1543:1633:1642","1887:1891"]},"author_link":["120052","120050","120060","120061","120057","120059","120047","120049","120055","120046","120054","120058","120056","120051","120048","120053"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Risk of cosmic radiation on human organs and tissues maintained in SCID mice and transgenerational effects"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"To study the risk of cosmic radiation, two projects, effects on human organs and tissues maintained in super-SCID mice and transgenerational effects in the offspring of mice exposed to radiation were carried out;. Morphological and functional (hormone secretion) changes and/or mutations were induced in human thyroid tissues by high doses and high dose rate of X- and gamma-rays (9-33 Gy) and reactor neutron (0.2 Gy x 6), but not by same doses with low dose-rate of gamma-rays, showing apparent dose rate effects in human thyroid tissues. Neutron (0.2 Gy x 4) induced bigger changes in gene expression than 2 Gy of gamma-rays, suggesting high RBE of neutron. Microsatellite mutations and lymphocytic leukemia were induced dose-dependently in the offspring of N5 male mice exposed to 0.2 and 0.4 Gy of neutron. The incidence was 10 folds higher than our former X-ray and gamma-ray studies, again suggesting high RBE.","subitem_description_type":"Other"}]},"item_5_description_18":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"形態: カラー図版あり","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064297016","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"医薬基盤研究所"},{"subitem_text_value":"医薬基盤研究所"},{"subitem_text_value":"医薬基盤研究所"},{"subitem_text_value":"大阪大学医学系研究科"},{"subitem_text_value":"大阪大学医学系研究科"},{"subitem_text_value":"近畿大学理工学部"},{"subitem_text_value":"近畿大学理工学部"},{"subitem_text_value":"神戸隈病院"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"National Institute of Biomedical Innovation"},{"subitem_text_language":"en","subitem_text_value":"National Institute of Biomedical Innovation"},{"subitem_text_language":"en","subitem_text_value":"National Institute of Biomedical Innovation"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medicine, Osaka University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medicine, Osaka University"},{"subitem_text_language":"en","subitem_text_value":"School of Science and Engineering, Kinki University"},{"subitem_text_language":"en","subitem_text_value":"School of Science and Engineering, Kinki University"},{"subitem_text_language":"en","subitem_text_value":"Kobe Kuma Hospital"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野村, 大成"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梁, 治子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"足立, 成基"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中島, 裕夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本行, 忠志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤川, 和男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 哲夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松塚, 文夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Taisei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ryo, Haruko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Hiroo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hongyo, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujikawa, Kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuzuka, Fumio","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64297016.pdf","filesize":[{"value":"620.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64297016.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13260/files/64297016.pdf"},"version_id":"5e083796-aceb-4a14-a058-d3cbb513b49a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Space Radiation, Neutron, Human Thyroid Gland, SCID Mice, Microsatellite Mutation, Leukemia, F(sub 1) Progeny","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価"}]},"item_type_id":"5","owner":"1","path":["1642","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13260","relation_version_is_last":true,"title":["ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:01:13.779711+00:00"}