@inproceedings{oai:jaxa.repo.nii.ac.jp:00013262,
 author = {大西, 武雄 and 高橋, 昭久 and 谷田貝, 文夫 and 鈴木, ひろみ and 嶋津, 徹 and 大森, 克徳 and 石岡, 憲昭 and Onishi, Takeo and Takahashi, Akihisa and Yatagai, Fumio and Suzuki, Hiromi and Shimazu, Toru and Omori, Katsunori and Ishioka, Noriaki},
 book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium},
 month = {Mar},
 note = {第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), The space environment contains two main biologically important factors, i.e. space radiations and microgravity. Space radiations are well known to contain heavy particles which induce serious damage in organisms with high relative biological effectiveness as compared with low LET radiations such as X-rays and gamma-rays. The tumor suppressor gene product p53 is generally thought to contribute to the genetic stability of DNA-damaged cells through p53-centered signal transduction pathways. We have already found the accumulation of p53 in the skin and muscle of rats after spaceflight. For the next stage, in the present study we propose to investigate the gene expression of p53-regulated genes in mammalian cultured cells after exposure to space environment. Human lymphoblastoid TSCE5 cells (carrying wild-type p53) and WTK1 cells (carrying mutant p53) are frozen until launching. The cells are molten and then cultured under micro g or 1 g at 37 C during 6 days in International Space Station. After re-freezing, the cells return on the Earth. The data obtained with flight samples will be compared with those of ground control samples. Finally, the experimental results from flight samples might clarify the role of p53-regulated or unknown genes in the genetic instability induced by space stressors. We expect that the data from this proposal will be useful for providing physiological protection against the serious effects of space radiation during long stays in space., 資料番号: AA0064297018},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)},
 title = {宇宙ステーションにおける宇宙放射線の生物影響研究(2)},
 volume = {25},
 year = {2009}
}