{"created":"2023-06-20T14:45:46.444450+00:00","id":13262,"links":{},"metadata":{"_buckets":{"deposit":"c771f209-d05e-4c86-837b-43fadf6b17f8"},"_deposit":{"created_by":1,"id":"13262","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13262"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013262","sets":["1543:1633:1642","1887:1891"]},"author_link":["120080","120088","120089","120076","120078","120083","120084","120077","120087","120079","120082","120086","120081","120085"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"The study of biological effects by space radiations in ISS (2)"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"The space environment contains two main biologically important factors, i.e. space radiations and microgravity. Space radiations are well known to contain heavy particles which induce serious damage in organisms with high relative biological effectiveness as compared with low LET radiations such as X-rays and gamma-rays. The tumor suppressor gene product p53 is generally thought to contribute to the genetic stability of DNA-damaged cells through p53-centered signal transduction pathways. We have already found the accumulation of p53 in the skin and muscle of rats after spaceflight. For the next stage, in the present study we propose to investigate the gene expression of p53-regulated genes in mammalian cultured cells after exposure to space environment. Human lymphoblastoid TSCE5 cells (carrying wild-type p53) and WTK1 cells (carrying mutant p53) are frozen until launching. The cells are molten and then cultured under micro g or 1 g at 37 C during 6 days in International Space Station. After re-freezing, the cells return on the Earth. The data obtained with flight samples will be compared with those of ground control samples. Finally, the experimental results from flight samples might clarify the role of p53-regulated or unknown genes in the genetic instability induced by space stressors. We expect that the data from this proposal will be useful for providing physiological protection against the serious effects of space radiation during long stays in space.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064297018","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"奈良県立医科大学"},{"subitem_text_value":"奈良県立医科大学"},{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"宇宙航空研究開発機構"},{"subitem_text_value":"宇宙航空研究開発機構"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Nara Medical University"},{"subitem_text_language":"en","subitem_text_value":"Nara Medical University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research (RIKEN)"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency (JAXA)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大西, 武雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 昭久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷田貝, 文夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, ひろみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"嶋津, 徹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大森, 克徳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onishi, Takeo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Akihisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatagai, Fumio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimazu, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Omori, Katsunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64297018.pdf","filesize":[{"value":"351.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64297018.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13262/files/64297018.pdf"},"version_id":"0f8b2ed8-2c7f-44b9-b97c-85325e625a52"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"International Space Station, space radiations, microgravity, p53-regulated genes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"宇宙ステーションにおける宇宙放射線の生物影響研究(2)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"宇宙ステーションにおける宇宙放射線の生物影響研究(2)"}]},"item_type_id":"5","owner":"1","path":["1642","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13262","relation_version_is_last":true,"title":["宇宙ステーションにおける宇宙放射線の生物影響研究(2)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:01:09.053869+00:00"}