@inproceedings{oai:jaxa.repo.nii.ac.jp:00013291, author = {池田, 通 and 粂井, 康宏 and 井奥, 洪二 and 権田, 芳範 and 柴田, 恭明 and 戸田, 一雄 and 関, 幸子 and Ikeda, Tohru and Kumei, Yasuhiro and Ioku, Koji and Gonda, Yoshinori and Shibata, Yasuaki and Toda, Kazuo and Seki, Sachiko}, book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium}, month = {Mar}, note = {第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), Osteoclast plays pivotal roles in bone metabolism. However, details of osteoclast activity in low gravity remain unknown. We have developed a unique osteoclast culture system using biodegradable and unbiodegradable ceramic discs. Using an ultrasensitive intracellular calcium analyzing system, we are studying change in intracellular calcium of active osteoclasts cultured on biodegradable ceramics and quiescent osteoclasts cultured on unbiodegradable ceramics. It is highly possible that low gravity changes function of calcium channels in osteoclasts and will change the intracellular calcium concentration very quickly. It has been shown that intracellular calcium affects osteoclast bioactivity. Hence, parabolic flight experiments will be able to clarify the mystery of osteoclast in space medical biology., 形態: カラー図版あり, 資料番号: AA0064297047}, publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)}, title = {平成20年度JAXA研究班WG活動報告. 活性型及び非活性型破骨細胞を用いた低重力実験: 要素技術の調査研究}, volume = {25}, year = {2009} }