{"created":"2023-06-20T14:45:47.772316+00:00","id":13292,"links":{},"metadata":{"_buckets":{"deposit":"e4ceec7b-c8a9-4768-a720-e3f614f7262d"},"_deposit":{"created_by":1,"id":"13292","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13292"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013292","sets":["1543:1633:1642","1887:1891"]},"author_link":["120444","120441","120440","120443","120439","120437","120438","120442"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Molecular mechanisms of the control of apoptosis by mechanical stress to bone"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_16":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"骨における力学刺激は、ユビキチンE3リガーゼを介して骨芽細胞および破骨細胞の細胞寿命変化を起こしうることが示された。また、IL-11 は骨芽細胞分化および骨芽細胞寿命制御に重要な役割を果たしているが、その転写調節にはERK/CREB/ΔFosB 系に加え、力学的負荷によるSmad1/5 のリン酸化を介したシグナルが標的遺伝子の転写調節を介して協調して働いていることが明らかとなった。本検討の成果は、宇宙における微少重力環境や不動状態における骨量減少の分子機序を明らかにするとともに、これらの病態に対する治療法開発にも有用であると考えられる。","subitem_description_type":"Abstract"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Mechanical stress in bone can alter the survival of both osteoblasts and osteoclasts via its effect on ubiquitin E3 ligase. Mechanical stress also enhances IL-11 expression via ERK/CREB/delta FosB signaling pathway along with phosphorylation/activation by PKC delta of Smad1/5 signaling. The increased delta FosB and activated Smad1/5 form complex and bind to AP-1 and SBE sites, respectively, on IL-11 gene promoter to enhance its transcription. The increased IL-11 by mechanical stress plays an important role in osteoblast development and survival. Further elucidation of the mechanism whereby osteoblast/osteoclast development and survival are regulated by mechanical stress should give us clues for the prevention of bone loss induced by micro-gravity and immobilization.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064297048","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"徳島大学大学院生体情報内科学"},{"subitem_text_value":"徳島大学大学院生体情報内科学"},{"subitem_text_value":"癌研究会研究所生化学部"},{"subitem_text_value":"東京大学大学院医学系研究科整形外科"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical Science, University of Tokushima"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical Science, University of Tokushima"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Cancer Institute of Japanede Foundarion for Cancer Reseach"},{"subitem_text_language":"en","subitem_text_value":"Department of Orthopaedic Surgery, Graduate School of Medicine, Univeristy of Tokyo"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 俊夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"遠藤, 逸朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今村, 健志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 栄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Itsuro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Sakae","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64297048.pdf","filesize":[{"value":"275.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64297048.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13292/files/64297048.pdf"},"version_id":"82c54344-c81b-4350-a736-35f71d23cd23"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"骨への力学的負荷によるアポトーシス制御とその分子機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨への力学的負荷によるアポトーシス制御とその分子機序の解明"}]},"item_type_id":"5","owner":"1","path":["1642","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13292","relation_version_is_last":true,"title":["骨への力学的負荷によるアポトーシス制御とその分子機序の解明"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T06:00:11.888730+00:00"}