@inproceedings{oai:jaxa.repo.nii.ac.jp:00013303,
 author = {渡部, 稔 and 柳澤, 誠 and 古野, 伸明 and 柏木, 啓子 and 花田, 秀樹 and 新海, 正 and 吉留, 賢 and 久保, 英夫 and 坂井, 雅夫 and 藤井, 博匡 and 山下, 雅道 and 柏木, 昭彦 and Watanabe, Minoru and Yanagisawa, Makoto and Furuno, Nobuaki and Kashiwagi, Keiko and Hanada, Hideki and Shinkai, Tadashi and Yoshitome, Satoshi and Kubo, Hideo and Sakai, Masao and Fujii, Hirotada and Yamashita, Masamichi and Kashiwagi, Akihiko},
 book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium},
 month = {Mar},
 note = {第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), Xenopus embryos raised under hypergravity condition develop a variety of abnormalities. Among them, head-defects such as microcephaly and cyclopia are the most common. Normal head formation is regulated by Wnt signaling. Inhibition of Wnt signaling causes head-defects in embryos, and ectopic activation of Wnt signaling induces extra body axis with head. Embryos are most sensitive to hypergravity within 30 min after fertilization, and activation of endogenous Wnt signaling occurs at almost the same time by cortical rotation which is sensitive to gravity. These facts suggest that the target of hypergravity might be Wnt signaling. In order to investigate this possibility, Wnt signaling activity in embryos raised under hypergravity conditions was analyzed by the measuring the expression of the Wnt-target genes. Quantitative RT-PCR revealed that the expression of some of Wnt-target genes was reduced in these embryos. This result strongly suggests that Wnt signaling is the target of the hypergravity derived head-defects in Xenopus embryos., 資料番号: AA0064297059},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)},
 title = {過重力下で見られるアフリカツメガエル頭部形成異常の解析},
 volume = {25},
 year = {2009}
}