{"created":"2023-06-20T14:45:48.265726+00:00","id":13303,"links":{},"metadata":{"_buckets":{"deposit":"dfc04972-fbbe-4f6f-956d-7064b8b9f8b6"},"_deposit":{"created_by":1,"id":"13303","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13303"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013303","sets":["1543:1633:1642","1887:1891"]},"author_link":["120707","120711","120720","120708","120709","120715","120716","120719","120717","120701","120712","120723","120710","120713","120718","120705","120702","120722","120714","120704","120706","120721","120703","120724"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of head-defects in Xenopus embryos raised under hypergravity condition"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム"},{"bibliographic_title":"Space Utilization Research: Proceedings of Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_14":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)","subitem_description_type":"Other"}]},"item_5_description_15":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）（英）","attribute_value_mlt":[{"subitem_description":"The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)","subitem_description_type":"Other"}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Xenopus embryos raised under hypergravity condition develop a variety of abnormalities. Among them, head-defects such as microcephaly and cyclopia are the most common. Normal head formation is regulated by Wnt signaling. Inhibition of Wnt signaling causes head-defects in embryos, and ectopic activation of Wnt signaling induces extra body axis with head. Embryos are most sensitive to hypergravity within 30 min after fertilization, and activation of endogenous Wnt signaling occurs at almost the same time by cortical rotation which is sensitive to gravity. These facts suggest that the target of hypergravity might be Wnt signaling. In order to investigate this possibility, Wnt signaling activity in embryos raised under hypergravity conditions was analyzed by the measuring the expression of the Wnt-target genes. Quantitative RT-PCR revealed that the expression of some of Wnt-target genes was reduced in these embryos. This result strongly suggests that Wnt signaling is the target of the hypergravity derived head-defects in Xenopus embryos.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0064297059","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)"}]},"item_5_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10324210","subitem_source_identifier_type":"NCID"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"徳島大学総合科学部"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"広島大学大学院理学研究科附属両生類研究施設"},{"subitem_text_value":"東京都老人総合研究所レドックス制御研究グループ"},{"subitem_text_value":"鳥取大学医学部生命科学科生体情報機能学講座"},{"subitem_text_value":"東京都臨床医学総合研究所神経生物学部門"},{"subitem_text_value":"鹿児島大学理学部"},{"subitem_text_value":"札幌医科大学保健医療学部"},{"subitem_text_value":"宇宙航空研究開発機構宇宙科学研究本部"},{"subitem_text_value":"山陽女子短期大学臨床検査学科"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Faculty of Integrated Arts and Sciences, University of Tokushima"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian Biology, Graduate School of Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian Biology, Graduate School of Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian Biology, Graduate School of Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Institute for Amphibian Biology, Graduate School of Science, Hiroshima University"},{"subitem_text_language":"en","subitem_text_value":"Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_language":"en","subitem_text_value":"Department of Biomedical Sciences, School of Life Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurobiology, Tokyo Metropolitan Institute of Medical Science"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Science, Kagoshima University"},{"subitem_text_language":"en","subitem_text_value":"School of Health Science, Sapporo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)"},{"subitem_text_language":"en","subitem_text_value":"Sanyo Women's College"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡部, 稔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柳澤, 誠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"古野, 伸明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柏木, 啓子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"花田, 秀樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"新海, 正"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉留, 賢"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久保, 英夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂井, 雅夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤井, 博匡"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山下, 雅道"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柏木, 昭彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Minoru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagisawa, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuno, Nobuaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashiwagi, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shinkai, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshitome, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Hideo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Hirotada","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Masamichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashiwagi, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"64297059.pdf","filesize":[{"value":"499.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64297059.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13303/files/64297059.pdf"},"version_id":"a2550e31-3aa7-44c1-aed2-d6ffedfdf1cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Xenopus, hypergravity, head formation, Wnt signaling, Quantitative RT-PCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"過重力下で見られるアフリカツメガエル頭部形成異常の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"過重力下で見られるアフリカツメガエル頭部形成異常の解析"}]},"item_type_id":"5","owner":"1","path":["1642","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13303","relation_version_is_last":true,"title":["過重力下で見られるアフリカツメガエル頭部形成異常の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:59:47.613011+00:00"}