@inproceedings{oai:jaxa.repo.nii.ac.jp:00013311,
 author = {谷田貝, 文夫 and 榎本, 秀一 and 高橋, 昭久 and 大西, 武雄 and 石岡, 憲昭 and 大森, 克徳 and 嶋津, 徹 and 鈴木, ひろみ and Yatagai, Fumio and Enomoto, Shuichi and Takahashi, Akihisa and Onishi, Takeo and Ishioka, Noriaki and Omori, Katsunori and Shimazu, Toru and Suzuki, Hiromi},
 book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium},
 month = {Mar},
 note = {第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), This paper is aimed to introduce how our developing methodologies for both loss of heterozygosity (LOH) analysis and DNA double-strand break (DSB) repair estimation are applied to detect the biological effects of space radiation. Our space experiments using human cultured cells in Kibou Facility of International Space Station (ISS) are planned to detect mutagenic effects (i), combined effects of radiation with micro gravity (ii), and radioadaptive response (iii). After cell recovery to the earth, we plan to do the following approaches for the above three biological effects: i) an LOH analysis for the mutants induced after the incubation of recovered frozen-cells exposed to low-dose space radiation during the 3 months preservation in ISS, ii) an examination for the existence of combined effects by comparing the mutation inductions between the cells incubated in ISS for ca. １ week under 1 G and those incubated under micro G, and iii) an estimation of the radioadaptive response from determination of the repair efficiencies of DSB introduced at the specific site of chromosome in the recovered cell., 形態: カラー図版あり, 資料番号: AA0064297067},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)},
 title = {ISSきぼう棟内での細胞培養実験による宇宙放射線影響研究},
 volume = {25},
 year = {2009}
}