{"created":"2023-06-20T14:45:56.155796+00:00","id":13434,"links":{},"metadata":{"_buckets":{"deposit":"4b31bb4d-a137-44f7-9215-5b419411f200"},"_deposit":{"created_by":1,"id":"13434","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13434"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013434","sets":["1543:1633:1643","1887:1891"]},"author_link":["122402","122404","122400","122403","122398","122405","122399","122401"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Inhibition of cell differentiation and aging using the simulating microgravity"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"229","bibliographicPageStart":"227","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第24回　平成19年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Little is known about cellular response such as proliferation, differentiation and gene expression to microgravity and this in part reflects lack of understanding of gravity-sensing and aging mechanisms. We investigated cell differentiation and aging of human mesenchymal stem cells and human normal osteoblasts cultured using the 3D-clinostat. Our results suggested that microgravity inhibited cell differentiation and aging. We propose that 3D-clinostat (Japanese original method) provides a novel method that contributes to cell therapy and developmental biology.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0063706058","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"広島大学 大学院"},{"subitem_text_value":"広島大学 大学院"},{"subitem_text_value":"広島大学 大学院"},{"subitem_text_value":"University of Texas Medical School"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Hiroshima University Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Hiroshima University Graduate School"},{"subitem_text_language":"en","subitem_text_value":"Hiroshima University Graduate School"},{"subitem_text_language":"en","subitem_text_value":"University of Texas Medical School"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"弓削, 類"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田原, 栄俊"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河原, 裕美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kulkarni, Anil D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yuge, Louis","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tahara, Hidetoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawahara, Yumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kulkarni, Anil D.","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"63706058.pdf","filesize":[{"value":"406.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"63706058.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13434/files/63706058.pdf"},"version_id":"2f62a056-c87d-49e5-ae9e-e7fd0ea49569"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"老化","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"微小重力","subitem_subject_scheme":"Other"},{"subitem_subject":"重力効果","subitem_subject_scheme":"Other"},{"subitem_subject":"クリノスタット","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"再生医療","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト間葉系幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"hMSC","subitem_subject_scheme":"Other"},{"subitem_subject":"末端小粒","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分裂","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞数測定","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞培養","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microgravity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gravitational effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clinostat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regenerative medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human mesenchymal stem cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hMSC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"telomere","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell division","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell 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