@inproceedings{oai:jaxa.repo.nii.ac.jp:00013436,
 author = {池田, 恭治 and 辰巳, 佐和子 and 石井, 清朗 and 小林, 利寛 and 竹下, 淳 and 網塚, 憲生 and Li, Minqi and 河野, 憲二 and 伊東, 昌子 and Ikeda, Kyoji and Tatsumi, Sawako and Ishii, Kiyoaki and Kobayashi, Toshihiro and Takeshita, Sunao and Amizuka, Norio and Li, Minqi and Kono, Kenji and Ito, Masako},
 book = {宇宙利用シンポジウム　第24回　平成19年度, Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium},
 month = {Mar},
 note = {Bone metabolism is performed by bone-degrading osteoclasts and bone-building osteoblasts on bone surface. The osteocyte is a third cell type in bone that is derived from osteoblast lineage cells and embedded in the mineralized matrix. In order to delineate the in vivo function of the osteocyte, we have developed a transgenic mouse model that enables targeted ablation of osteocytes following a single injection of diphtheria toxin. Under normal loading condition, ablation of osteocytes caused aberrant activation of osteoclastic bone resorption with elevated expression of RANKL (Receptor Activator of NF-KB Ligand). In contrast, during unloading by tail suspension, the osteocyte-depleted mice were protected from disuse-induced bone atrophy. These data suggest that osteocytes play a pivotal role in sensing and/or transducing mechanical signals to adapt the structure and function of bone according to changing mechanical environments., 資料番号: AA0063706060},
 pages = {234--235},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)},
 title = {骨の機械応答とosteocyte},
 year = {2008}
}