{"created":"2023-06-20T14:45:56.294477+00:00","id":13436,"links":{},"metadata":{"_buckets":{"deposit":"74c33709-fcd2-4ede-81a5-7494b0387f8d"},"_deposit":{"created_by":1,"id":"13436","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13436"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013436","sets":["1543:1633:1643","1887:1891"]},"author_link":["122442","122437","122443","122434","122440","122429","122438","122430","122433","122426","122439","122431","122428","122436","122441","122432","122427","122435"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Osteocytes in the skeletal response to weightlessness"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"235","bibliographicPageStart":"234","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第24回　平成19年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Bone metabolism is performed by bone-degrading osteoclasts and bone-building osteoblasts on bone surface. The osteocyte is a third cell type in bone that is derived from osteoblast lineage cells and embedded in the mineralized matrix. In order to delineate the in vivo function of the osteocyte, we have developed a transgenic mouse model that enables targeted ablation of osteocytes following a single injection of diphtheria toxin. Under normal loading condition, ablation of osteocytes caused aberrant activation of osteoclastic bone resorption with elevated expression of RANKL (Receptor Activator of NF-KB Ligand). In contrast, during unloading by tail suspension, the osteocyte-depleted mice were protected from disuse-induced bone atrophy. These data suggest that osteocytes play a pivotal role in sensing and/or transducing mechanical signals to adapt the structure and function of bone according to changing mechanical environments.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0063706060","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"国立長寿医療センター 運動器疾患研究部"},{"subitem_text_value":"国立長寿医療センター 運動器疾患研究部"},{"subitem_text_value":"国立長寿医療センター 運動器疾患研究部"},{"subitem_text_value":"国立長寿医療センター 運動器疾患研究部"},{"subitem_text_value":"国立長寿医療センター 運動器疾患研究部"},{"subitem_text_value":"新潟大学 超域研究機構"},{"subitem_text_value":"新潟大学 超域研究機構"},{"subitem_text_value":"奈良先端科学技術大学院大学 バイオサイエンス研究科"},{"subitem_text_value":"長崎大学 医学部・歯学部附属病院"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute"},{"subitem_text_language":"en","subitem_text_value":"National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute"},{"subitem_text_language":"en","subitem_text_value":"National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute"},{"subitem_text_language":"en","subitem_text_value":"National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute"},{"subitem_text_language":"en","subitem_text_value":"National Center for Geriatrics and Gerontology Department of Bone and Joint Disease, Research Institute"},{"subitem_text_language":"en","subitem_text_value":"Niigata University Center for Transdisciplinary Research"},{"subitem_text_language":"en","subitem_text_value":"Niigata University Center for Transdisciplinary Research"},{"subitem_text_language":"en","subitem_text_value":"Nara Institute of Science and Technology Graduate School of Biological Sciences"},{"subitem_text_language":"en","subitem_text_value":"Nagasaki University Hospital of Medicine and Dentistry"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 恭治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辰巳, 佐和子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石井, 清朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小林, 利寛"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹下, 淳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"網塚, 憲生"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Minqi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河野, 憲二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊東, 昌子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Kyoji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tatsumi, Sawako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Kiyoaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeshita, Sunao","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amizuka, Norio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Minqi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kono, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Masako","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"63706060.pdf","filesize":[{"value":"206.5 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effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoporosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acclimatization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone mineral content","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tail suspension","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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