@inproceedings{oai:jaxa.repo.nii.ac.jp:00013437,
 author = {宮本, 泰則 and 石川, 祐希 and 最上, 善広 and Miyamoto, Yasunori and Ishikawa, Yuki and Mogami, Yoshihiro},
 book = {宇宙利用シンポジウム　第24回　平成19年度, Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium},
 month = {Mar},
 note = {It is reported that a change of gravity environment affects the growth and function of some cultured cells. But the gravity response mechanism is not well characterized. We hypothesize that a gravity change is sensed through a cytoskeleton (tensegrity model) and transduced into biochemical signals by major extracellular matrix receptor, integrin. In this paper, we examined the effect of hypergravity (60 G) on the formation of actin stress fibers in mouse osteoblast cell line MC3T3-E1. The hypergravity induced a reorganization of the stress fibers. The reorganization was reversible by a removal of the hypergravity loading. Partial destruction of stress fiber formation with cytochalasin B and GRGDS peptide was recovered by hypergravity loading. The reorganization of stress fivers by hypergravity was inhibited with a Rho kinase inhibitor, Y-27632, indicating that Rho kinase plays a critical role in the reorganization of actin stress fiber formation by hypergravity loading. This study is part of activities of the working group of Science Steering Committee for Space Utilization, JAXA-ISAS., 資料番号: AA0063706061},
 pages = {236--237},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)},
 title = {過重力負荷による骨芽細胞株MC3T3-E1でのアクチンストレスファイバー再構成誘導},
 year = {2008}
}