{"created":"2023-06-20T14:45:56.360482+00:00","id":13437,"links":{},"metadata":{"_buckets":{"deposit":"3e1d6466-527f-459d-8414-8f587045f68a"},"_deposit":{"created_by":1,"id":"13437","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13437"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013437","sets":["1543:1633:1643","1887:1891"]},"author_link":["122446","122449","122445","122447","122444","122448"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Hypergravity induces reorganization of actin stress fiber assembly in osteoblastic MC3T3-E1 cells"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"237","bibliographicPageStart":"236","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第24回　平成19年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"It is reported that a change of gravity environment affects the growth and function of some cultured cells. But the gravity response mechanism is not well characterized. We hypothesize that a gravity change is sensed through a cytoskeleton (tensegrity model) and transduced into biochemical signals by major extracellular matrix receptor, integrin. In this paper, we examined the effect of hypergravity (60 G) on the formation of actin stress fibers in mouse osteoblast cell line MC3T3-E1. The hypergravity induced a reorganization of the stress fibers. The reorganization was reversible by a removal of the hypergravity loading. Partial destruction of stress fiber formation with cytochalasin B and GRGDS peptide was recovered by hypergravity loading. The reorganization of stress fivers by hypergravity was inhibited with a Rho kinase inhibitor, Y-27632, indicating that Rho kinase plays a critical role in the reorganization of actin stress fiber formation by hypergravity loading. This study is part of activities of the working group of Science Steering Committee for Space Utilization, JAXA-ISAS.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0063706061","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"お茶の水女子大学 大学院人間文化創成科学研究科"},{"subitem_text_value":"お茶の水女子大学 大学院人間文化創成科学研究科"},{"subitem_text_value":"お茶の水女子大学 大学院人間文化創成科学研究科"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Ochanomizu University Graduate School of Humanities and Sciences"},{"subitem_text_language":"en","subitem_text_value":"Ochanomizu University Graduate School of Humanities and Sciences"},{"subitem_text_language":"en","subitem_text_value":"Ochanomizu University Graduate School of Humanities and Sciences"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮本, 泰則"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石川, 祐希"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"最上, 善広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyamoto, Yasunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mogami, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"63706061.pdf","filesize":[{"value":"251.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"63706061.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13437/files/63706061.pdf"},"version_id":"c44c92f1-1960-4ace-9e9f-d9bd7ba92d50"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"テンセグリティー構造","subitem_subject_scheme":"Other"},{"subitem_subject":"アクチンストレス繊維","subitem_subject_scheme":"Other"},{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞骨格","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカラシン","subitem_subject_scheme":"Other"},{"subitem_subject":"重力生理学","subitem_subject_scheme":"Other"},{"subitem_subject":"高重力環境","subitem_subject_scheme":"Other"},{"subitem_subject":"遠心機","subitem_subject_scheme":"Other"},{"subitem_subject":"遠心ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞培養","subitem_subject_scheme":"Other"},{"subitem_subject":"重力効果","subitem_subject_scheme":"Other"},{"subitem_subject":"生理学的応答","subitem_subject_scheme":"Other"},{"subitem_subject":"cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tensegrity structure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"actin stress fiber","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"integrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytoskeleton","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytochalasin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gravitational physiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"high gravity environment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"centrifuge","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"centrifuging stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell culturing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gravitational effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"physiological response","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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