{"created":"2023-06-20T14:45:57.040795+00:00","id":13448,"links":{},"metadata":{"_buckets":{"deposit":"ece10e63-7b07-4111-bccc-23bda200d5c7"},"_deposit":{"created_by":1,"id":"13448","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13448"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013448","sets":["1543:1633:1643","1887:1891"]},"author_link":["122544","122551","122546","122548","122547","122553","122550","122554","122555","122545","122552","122549"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Type 5 adenylyl cyclase stimulater might be useful for the treatment of autonomic dysfunction after spaceflight?"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"268","bibliographicPageStart":"267","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第24回　平成19年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"We have demonstrated that type 5 Adenylyl Cyclase (AC5), a major cardiac AC isoform, plays a major role in determining the magnitude of cardiac response to autonomic regulation under microgravity using transgenic mouse models with either disrupted or overexpressed AC5 in the heart (Space Utiliz Res 23, 267-268, 2007). To test the hypothesis that specific AC5 stimulator (NKH477) may be useful for the treatment of autonomic dysfunction after spaceflight, we implanted osmotic mini-pump (1 mg/kg/day) in wild-type mice and analyzed heart rate variability during parabolic flight. The standard deviation of normal R-R intervals, a marker of total autonomic variability, was increased under microgravity in each group. However, the magnitude of the increase was much smaller in NKH477 group. We also examined the ratio between Low Frequency (LF) and High Frequency (HF), a marker of sympathetic activity, and normalized HF, a marker of parasympathetic activity, and found that these parameters in NKH477 group were similar to those in cardiac-specific AC5 overexpression mice we have previously examined. These results indicate that NKH477 could be able to stabilize the changes in autonomic indexes in response to microgravity, suggesting that it may be a useful for the treatment of autonomic dysfunction after spaceflight.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0063706072","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"横浜市立大学 大学院医学研究科"},{"subitem_text_value":"横浜市立大学 大学院医学研究科"},{"subitem_text_value":"横浜市立大学 大学院医学研究科"},{"subitem_text_value":"横浜市立大学 大学院医学研究科"},{"subitem_text_value":"横浜市立大学 大学院医学研究科"},{"subitem_text_value":"横浜市立大学 大学院医学研究科"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Yokohama City University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Yokohama City University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Yokohama City University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Yokohama City University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Yokohama City University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Yokohama City University Graduate School of Medicine"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥村, 敏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bai, Yunzhe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"黒谷, 玲子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 元彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"南沢, 享"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石川, 義弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bai, Yunzhe","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurotani, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Motohiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minamisawa, Susumu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"63706072.pdf","filesize":[{"value":"213.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"63706072.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13448/files/63706072.pdf"},"version_id":"c7fd8a19-1b16-4068-9a43-b831ac40d2bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自律神経系","subitem_subject_scheme":"Other"},{"subitem_subject":"交感神経系","subitem_subject_scheme":"Other"},{"subitem_subject":"刺激薬","subitem_subject_scheme":"Other"},{"subitem_subject":"5型アデニル酸シクラーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"AC5","subitem_subject_scheme":"Other"},{"subitem_subject":"NKH477","subitem_subject_scheme":"Other"},{"subitem_subject":"放物線飛行","subitem_subject_scheme":"Other"},{"subitem_subject":"薬","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"微小重力","subitem_subject_scheme":"Other"},{"subitem_subject":"心電図","subitem_subject_scheme":"Other"},{"subitem_subject":"パワースペクトル","subitem_subject_scheme":"Other"},{"subitem_subject":"自律神経調節","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子導入マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"autonomic nervous system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sympathetic nervous system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stimulant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"type 5 adenylyl cyclase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AC5","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NKH477","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"parabolic flight","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microgravity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electrocardiography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"power spectrum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autonomic regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"5型アデニル酸シクラーゼ刺激薬は微小重力下での自律神経調節障害の治療薬になりうるか?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"5型アデニル酸シクラーゼ刺激薬は微小重力下での自律神経調節障害の治療薬になりうるか?"}]},"item_type_id":"5","owner":"1","path":["1643","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13448","relation_version_is_last":true,"title":["5型アデニル酸シクラーゼ刺激薬は微小重力下での自律神経調節障害の治療薬になりうるか?"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:55:04.393138+00:00"}