@inproceedings{oai:jaxa.repo.nii.ac.jp:00013461,
 author = {跡見, 順子 and 藤田, 恵理 and 大澤, 具洋 and 桜井, 隆史 and 高沖, 宗夫 and 山下, 雅道 and 原田, 崇広 and 石原, 一彦 and 鈴木, 孝昌 and 渡辺, 敏行 and Atomi, Yoriko and Fujita, Eri and Osawa, Tomohiro and Sakurai, Takashi and Takaoki, Muneo and Yamashita, Masamichi and Harada, Takahiro and Ishihara, Kazuhiko and Suzuki, Takayoshi and Watanabe, Toshiyuki},
 book = {宇宙利用シンポジウム　第24回　平成19年度, Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium},
 month = {Mar},
 note = {Gravity is one of factors to maintain our living system to be active and healthy, because our biological system is constructed based on at least three important conditions under gravity on the earth as follows: (1) activity-dependent system at both levels of the cell and body, (2) morpho-dynamic system constituted of the cytoskeleton and extracellular matrix as, and (3) self organization to keep centering their mass at both levels of the cell and body. Such a system is organized by dynamically regulated protein filament system, such as actin, tubulin/MicroTubule (MT) and intermediate filament system. The use of filaments (the cytoskeleton, which is regulated with dynamic property) must be essential for maintaining shape responding own mobile activity intrinsic for especially animals under the gravity on the earth. Keeping such a morpho-dynamic system needs molecular chaperone, which takes care of free forms of proteins to keep equilibrium balancing free forms and filamentous forms, which has various functional properties of polarity, pushing ability, making various shapes and making fulcrum in the association with other protein complex at focal adhesion and extracellular matrix. Striated muscles are typical organized form that we can analyze a mechanism of two cytoskeleton systems of actin and tubulin/microtubule, because they work with balanced force each other under physiological condition against calcium oscillation per each beating. These organization of the cytoskeleton realizes autonomic beating like everlasting nonstop ping machine. It is interesting to study that what factors strongly relates to autonomous system, quantity of tension, and dynamic property. Studies to characterize tubulin/MT are rare in striated muscles. Beating heart expresses molecular chaperone alpha B-crystallin like as untigravitational muscle, which may support continuous beating keeping dynamic instability by taking care of chaperoning free forms of tubulin, actin and intermediate filament. Under space the expression levels of alpha B-crystallin may decrease because of the unloaded work performed by cardiac myocyte., 資料番号: AA0063706085},
 pages = {302--303},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)},
 title = {統合・代替医科学的問題と重力健康科学の展望:心筋細胞の形・ダイナミクスから考える},
 year = {2008}
}