@inproceedings{oai:jaxa.repo.nii.ac.jp:00013468, author = {鈴木, 雅雄 and 古澤, 佳也 and 鶴岡, 千鶴 and 小林, 克己 and 宇佐美, 徳子 and 前田, 宗利 and 舟山, 知夫 and 坂下, 哲哉 and 横田, 裕一郎 and 深本, 花菜 and Suzuki, Masao and Furusawa, Yoshiya and Tsuruoka, Chizuru and Kobayashi, Katsumi and Usami, Noriko and Maeda, Munetoshi and Funayama, Tomoo and Sakashita, Tetsuya and Yokota, Yuichiro and Fukamoto, Kana}, book = {宇宙利用シンポジウム 第24回 平成19年度, Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium}, month = {Mar}, note = {We have begun to investigate cellular bystander responses in normal human fibroblasts induced by microbeams of different radiation types. This year, we used two different microbeams, such as carbon ions as high-LET (Linear Energy Transfer) radiations and X rays as low-LET radiations. Carbon-ion microbeams ((12)C(5+), 220 MeV) were generated with the Takasaki Ion Accelerators for Advanced Radiation Application (TIARA) at Japan Atomic Energy Agency. Mono-energetic X-ray (5.35 keV) microbeams were produced with the Photon Factory (PF) at High Energy Accelerator Research Organization. We designed that only 0.2 percent of total cells was irradiated with each microbeam. The percent cell survival in microbeam-irradiated dishes was ranging from 83 percent to 94 percent for carbon ions, while around 100 percent for X rays. Mutation frequency for carbon-ion-microbeam irradiated cells was about 6 times higher than that for non-irradiated control cells, but there was no difference in mutation frequency between X-ray-microbeam irradiated and control cells. There is clear evidence that bystander cellular effects induced by low-dose radiations depends on a radiation quality., 資料番号: AA0063706092}, pages = {328--330}, publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)}, title = {マイクロビーム放射線照射法を利用した低線量(率)・低フルエンス照射に対するヒト正常細胞の細胞応答の線質依存性}, year = {2008} }