@inproceedings{oai:jaxa.repo.nii.ac.jp:00013470, author = {谷田貝, 文夫 and 本間, 正充 and 石岡, 憲昭 and 大森, 克徳 and 嶋津, 徹 and 鈴木, ひろみ and Yatagai, Fumio and Honma, Masamitsu and Ishioka, Noriaki and Omori, Katsunori and Shimazu, Toru and Suzuki, Hiromi}, book = {宇宙利用シンポジウム 第24回 平成19年度, Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium}, month = {Mar}, note = {DNA (DeoxyriboNucleic Acid) Double-Strand Break (DSB) was introduced by the I-Sce I expression vector, pCBASce. Repair of DSB introduced by the I-SceI expression vector at the tk+ allele in human lymphoblstoid TK6 cell line, TSCE5, was measured by induction of TK-deficient mutants. Similarly we also measured the revertants due to such repair in its compound heterozygote (tk-/-) cell line, TSCER2, which carried an additional point-mutation in exon 5. The former and later measurements reflect the DSB repair efficiency due to DNA Non-Homologous End-Joining (NHEJ) and Homologous Recombination (HR), respectively. The pre-treatment, C-ion-irradiation of frozen cells, TSCE5 and TSCER2 with 50 mGy enhanced DSB repair due to both pathways of NHEJ and HR, 2 to 3-fold. This kind of adaptive response might be observed with the cells recovered from the long preservation under the frozen status in ISS (International Space Station)., 資料番号: AA0063706094}, pages = {333--334}, publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)}, title = {凍結細胞への低線量放射線影響を適応応答効果として検出する試み}, year = {2008} }