@inproceedings{oai:jaxa.repo.nii.ac.jp:00013471,
 author = {大西, 武雄 and 高橋, 昭久 and Onishi, Takeo and Takahashi, Akihisa},
 book = {宇宙利用シンポジウム　第24回　平成19年度, Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium},
 month = {Mar},
 note = {The space environment contains two main biologically important factors, i.e. space radiations and microgravity. Space radiations are well known to contain heavy particles which induce serious damage in organisms with high relative biological effectiveness as compared with low LET (Linear Energy Transfer) radiations such as X-rays and gamma-rays. Therefore, study of the biological effects of space radiations is very important when we aim to stay long term in space. In 2005, we organized the WG of 'the study of biological effects by space radiations in ISS (International Space Station)' including radiation biologists and physicists in Japan. We discussed the next stage of space experiments. On the other hand PI of this WG will carry out of space experiment 'RadGene' program in 2008. In 'RadGene' program, the PI propose to investigate the gene expression of p53-regulated genes in mammalian cultured cells (human lymphoblastoid TK6 cells carrying wild-type p53 and WTK1 cells, a sub-clone of TK6 carrying mutant p53) after exposure to space environment. The tumor suppressor gene product p53 is generally thought to contribute to the genetic stability of DNA (DeoxyriboNucleic Acid)-damaged cells through p53-centered signal transduction pathways. Then, the members of this WG will discuss the additional experiments using 'RadGene' samples. We expect that the data from this proposal will contribute to protect biological and physiological effects for human body from space radiations during long stays in space., 資料番号: AA0063706095},
 pages = {335--336},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)},
 title = {宇宙ステーションにおける宇宙放射線の生物影響研究},
 year = {2008}
}