{"created":"2023-06-20T14:46:03.280807+00:00","id":13572,"links":{},"metadata":{"_buckets":{"deposit":"f534dc0b-c6db-45b7-962c-1d736d548597"},"_deposit":{"created_by":1,"id":"13572","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13572"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013572","sets":["1543:1633:1644","1887:1891"]},"author_link":["123970","123973","123971","123972"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"The effect of venous return on arterial cardiac baroreflex function"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"266","bibliographicPageStart":"264","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第23回　平成18年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"In a previous study, we demonstrated that simulated microgravity (head-down-tilt bed rest) leads to a reduction in plasma volume and decreases in spontaneous arterial-cardiac baroreflex function; however repeated exposure to hypergravity leads to increases in plasma volume and baroreflex function. From these results, it is hypothesized that spontaneous arterial-cardiac baroreflex function may be dependent on venous return or central blood volume. Despite extensive study of cardiovascular reflex control after spaceflight, bed rest or hypergravity, there is no reports demonstrating in the same subjects that both acute hypovolemia and hypervolemia lead to changes of cardiac baroreflex function in a 'simple linear dose-dependent' manner. Therefore, we conducted this study to quantify the possible dose-effect relationship between the venous return (central blood volume) and baroreflex regulation of heart rate, by using transfer function analysis and Sequence Technique between spontaneous changes in arterial pressure and R-R interval during acute central hypovolemia (LBNP (Lower Body Negative Pressure) -15, -30 mmHg or furosemide administration) and hypervolemia (saline infusion 15, 30 ml/kg). High frequency transfer function gain and slope of Sequence Technique, as indexes of arterial-cardiac baroreflex function, elevated with increases in central venous pressure or LVEDV (Left Ventricular End-Diastolic Volume), from central hypovolemia of -30 mmHg LBNP to hypervolemia of 15 ml/kg saline infusion. However, these baroreflex indexes decreased at hypervolemia of 30 ml/kg saline infusion. These results may suggest that spontaneous arterial-cardiac baroreflex function is directly proportional to venous return within a certain range, although the baroreflex function is reduced when central blood volume rises over the range. The analysis of this dose-effect relationship can be used for further understanding of the changes in baroreflex function induced by simulated microgravity or space flight.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0063349074","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"日本大学 医学部　社会医学講座"},{"subitem_text_value":"日本大学 医学部　麻酔学講座"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Nihon University Department of Social Medicine, School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Nihon University Department of Anesthesiology, School of Medicine"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩崎, 賢一"}],"nameIdentifiers":[{"nameIdentifier":"123970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 実"}],"nameIdentifiers":[{"nameIdentifier":"123971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwasaki, Kenichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"123972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Jitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"123973","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-20"}],"displaytype":"detail","filename":"63349074.pdf","filesize":[{"value":"99.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"63349074.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13572/files/63349074.pdf"},"version_id":"2a71b980-fa34-47c1-8741-530ad7f4eb60"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"静脈還流","subitem_subject_scheme":"Other"},{"subitem_subject":"圧反射","subitem_subject_scheme":"Other"},{"subitem_subject":"血流量減少","subitem_subject_scheme":"Other"},{"subitem_subject":"下半身陰圧負荷","subitem_subject_scheme":"Other"},{"subitem_subject":"起立耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"微小重力","subitem_subject_scheme":"Other"},{"subitem_subject":"圧受容器","subitem_subject_scheme":"Other"},{"subitem_subject":"血流量","subitem_subject_scheme":"Other"},{"subitem_subject":"交感神経系","subitem_subject_scheme":"Other"},{"subitem_subject":"血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"心電図","subitem_subject_scheme":"Other"},{"subitem_subject":"血漿体積","subitem_subject_scheme":"Other"},{"subitem_subject":"シーケンス法","subitem_subject_scheme":"Other"},{"subitem_subject":"LBNP","subitem_subject_scheme":"Other"},{"subitem_subject":"venous return","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"baroreflex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypovolemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lower body negative pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"orthostatic tolerance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microgravity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"baroreceptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"blood volume","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sympathetic nervous system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"blood pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electrocardiography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasma volume","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sequence technique","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LBNP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"静脈還流量の変化が圧受容器反射機能に及ぼす効果の量影響関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"静脈還流量の変化が圧受容器反射機能に及ぼす効果の量影響関係"}]},"item_type_id":"5","owner":"1","path":["1644","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13572","relation_version_is_last":true,"title":["静脈還流量の変化が圧受容器反射機能に及ぼす効果の量影響関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:51:02.915748+00:00"}