@inproceedings{oai:jaxa.repo.nii.ac.jp:00013573, author = {石川, 義弘 and 南沢, 享 and 佐藤, 元彦 and 奥村, 敏 and Ishikawa, Yoshihiro and Minamisawa, Susumu and Sato, Motohiko and Okumura, Satoshi}, book = {宇宙利用シンポジウム 第23回 平成18年度, Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium}, month = {Mar}, note = {We used transgenic mouse models with either disrupted (AC5KO) or overexpressed AC5 in the heart (AC5TG), and analyzed Heart Rate Variability (HRV) in pre-microgravity level flight, under microgravity, and in post-microgravity level flight during parabolic flight. Heart rate under microgravity became lower than that in pre-microgravity level flight in Wild Type (WT) and AC5TG while it was unchanged in AC5KO. The ratio between Low Frequency (LF) and High Frequency (HF) in HRV analysis became significantly lower under microgravity in WT and AC5TG while there was no such a decrease in AC5KO. Normalized HF became significantly greater in WT under microgravity, and became even greater in AC5TG. In contrast, there was no such increase in AC5KO under microgravity. Accordingly, changes in autonomic indexes in response to microgravity were augmented in AC5TG while attenuated in AC5KO, suggesting that the amount of AC5 plays a major role in determining the magnitude of cardiac responses, at least, to microgravity., 資料番号: AA0063349075}, pages = {267--268}, publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)}, title = {微小重力下での自律神経による心機能制御の検討}, year = {2007} }