{"created":"2023-06-20T14:46:03.842225+00:00","id":13585,"links":{},"metadata":{"_buckets":{"deposit":"2ed07f31-7faa-4a9d-a39d-4bcf45a4b0de"},"_deposit":{"created_by":1,"id":"13585","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13585"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013585","sets":["1543:1633:1644","1887:1891"]},"author_link":["124128","124125","124130","124131","124135","124137","124126","124127","124129","124136","124134","124124","124132","124122","124123","124133"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Repair of DSB at a specific site of chromosome: Influence of low-dose/low-dose-rate gamma-rays"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"308","bibliographicPageStart":"305","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第23回　平成18年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"DSB (Double Strand Break) was introduced by the I-Sce I expression vector, pCMV3xnls-I-Sce I. Repair of DSB at the I-SceI site inserted at intron 4 of the tk+ allele in human lymphoblstoid TK6 cell line, TSCE5, was measured by induction of TK-deficient mutants. Similarly we also measured the revertants due to such repair in its compound heterozygote (tk-/-) cell line, TSCER2, which carried an additional point-mutation in exon 5. The former and later measurements reflect the DSB repair efficiency due to DNA End-Joining (EJ) and Homologous Recombination (HR), respectively. The pre-treatment, gamma-irradiation with 30 mGy at a dose rate of 1.2 mGy/hr did not influence the EJ repair efficiency but enhanced HR repair efficiency, approximately 50 percent. The I-SceI digestion followed by much lower dose(/dose-rate) gamma-irradiation (8.5 mGy at 0.125 mGy/hr) during the incubation tesulted in a similar tendency of HR enhancement (approximately 50 percent). This kind of treatment, introducing the chromosome break by the restriction enzyme, can be regarded as a useful approach for elucidating the influences of space environments on the DSB repair.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0063349087","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"理化学研究所"},{"subitem_text_value":"国立医薬品食品衛生研究所"},{"subitem_text_value":"放射線医学総合研究所"},{"subitem_text_value":"宇宙航空研究開発機構 宇宙科学研究本部"},{"subitem_text_value":"日本宇宙フォーラム"},{"subitem_text_value":"日本宇宙フォーラム"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physical and Chemical Research"},{"subitem_text_language":"en","subitem_text_value":"National Institute of Health Sciences"},{"subitem_text_language":"en","subitem_text_value":"National Institute of Radiological Sciences"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency Institute of Space and Astronautical Science"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"},{"subitem_text_language":"en","subitem_text_value":"Japan Space Forum"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷田貝, 文夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梅林, 志浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩木, 正哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本間, 正充"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 雅雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"嶋津, 徹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, ひろみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatagai, Fumio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umebayashi, Yukihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwaki, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"63349087.pdf","url":"https://jaxa.repo.nii.ac.jp/record/13585/files/63349087.pdf"},"version_id":"81332d13-2086-4ece-9446-d2b97eb467c3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"染色体","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線影響","subitem_subject_scheme":"Other"},{"subitem_subject":"ガンマ線","subitem_subject_scheme":"Other"},{"subitem_subject":"培養細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"生物学的影響","subitem_subject_scheme":"Other"},{"subitem_subject":"航空宇宙環境","subitem_subject_scheme":"Other"},{"subitem_subject":"血液細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"2重鎖切断","subitem_subject_scheme":"Other"},{"subitem_subject":"DSB","subitem_subject_scheme":"Other"},{"subitem_subject":"非相同末端結合","subitem_subject_scheme":"Other"},{"subitem_subject":"EJ","subitem_subject_scheme":"Other"},{"subitem_subject":"相同組替え","subitem_subject_scheme":"Other"},{"subitem_subject":"HR","subitem_subject_scheme":"Other"},{"subitem_subject":"chromosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation 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