@inproceedings{oai:jaxa.repo.nii.ac.jp:00013589,
 author = {鈴木, 信雄 and 大森, 克徳 and 井尻, 憲一 and 北村, 敬一郎 and 清水, 宣明 and 田畑, 純 and 池亀, 美華 and 中村, 正久 and 近藤, 隆 and 松田, 恒平 and Suzuki, Nobuo and Omori, Katsunori and Ijiri, Kenichi and Kitamura, Keiichiro and Shimizu, Nobuaki and Tabata, Makoto J. and Ikegame, Mika and Nakamura, Masahisa and Kondo, Takashi and Matsuda, Kohei},
 book = {宇宙利用シンポジウム　第23回　平成18年度, Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium},
 month = {Mar},
 note = {In osteoclast activity during space flight, inconsistent results have been reported in an in vivo study while osteoblastic function is consistently reduced by space flight. Bone matrix is an important function in the response to physical stress. However, there is no suitable in vitro co-culture system of osteoblasts and osteoclasts including bone matrix. On the other hand, fish scale is a calcified tissue that contains osteoblasts, osteoclasts, and bone matrix, all of which are similar to those found in human bones. Recently, we developed a new in vitro model system using goldfish scale. This system can be used to simultaneously detect the activities of both scale osteoclasts and osteoblasts with tartrate-resistant acid phosphatase and alkaline phosphatase as the respective markers and precisely analyze the co-relationship between osteoblasts and osteoclasts. In our co-culture system, osteoblasts and osteoclasts reacted sensitively to several degrees of acceleration, ultrasound stimulation, and micro-gravity of 3D clinostat. Therefore, we strongly believe that our in vitro co-culture system is suitable model for the analysis of bone metabolism under micro-gravity, such as that experienced in space flight., 資料番号: AA0063349091},
 pages = {318--321},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)},
 title = {魚類のウロコを用いた宇宙生物学的研究},
 year = {2007}
}