@inproceedings{oai:jaxa.repo.nii.ac.jp:00013683, author = {菅谷, 茂 and 喜多, 和子 and 鈴木, 敏和 and 金井, 和美 and 一村, 義信 and 郭, 文智 and 紀, 仲秋 and 呂, 軍 and ?, 暁波 and 伊藤, 勇夫 and 鈴木, 信夫 and Sugaya, Shigeru and Kita, Kazuko and Suzuki, Toshikazu and Kanai, Kazumi and Ichimura, Nobuyuki and Wen, Zhi Guo and Zhong, Qiu-Ji and Xiao-Bo, Tong and Ito, Isao and Suzuki, Nobuo}, book = {宇宙利用シンポジウム, Space Utilization Research: Proceedings of Space Utilization Symposium}, month = {Mar}, note = {第22回宇宙利用シンポジウム(2006年1月17日-19日, 日本学術会議6階会議室 六本木、東京), The Twenty-second Space Utilization Symposium (January 17-19, 2006: Science Council of Japan, Roppongi, Tokyo, Japan), Free-fall (FF) with a drop shaft and the paraboric flight (PF) are utilized to mimic a microgravity environment. In this study, we examined whether modulating activity of serum factors on cell mutability is changed in rats subjected to FF and human subjected to PF. Cultured human cells were treated with serum and then irradiated with UV. Mutagenicity was estimated by identification of K-ras codon 12 base substitution mutation or by detection of ouabain-resistance (Oua(sup R)) mutation. Modulating activity was detected in samples exposed to FF and moreover one sample from post-PF serum., 共催: 日本学術会議, 著者人数: 11人, Meeting sponsors: The Science Council of Japan, The Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA), 資料番号: AA0064113066}, publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)}, title = {ヒトおよびラットにおける変異誘導発生に及ぼす重力変動ストレス}, volume = {22}, year = {2006} }