@inproceedings{oai:jaxa.repo.nii.ac.jp:00013776,
 author = {東端, 晃 and 佐藤今溝, 真理 and 関, 真也 and 石岡, 憲昭 and Higashibata, Akira and SatoImamizo, Mari and Seki, Masaya and Ishioka, Noriaki},
 book = {宇宙利用シンポジウム　第21回　平成16年度, Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium},
 month = {Mar},
 note = {It has been reported that actin stress fiber and microtubule were disorganized under microgravity. But the mechanism of these disorganizations is unclear. In the last symposium, it was reported that the effect of gene expression in bovine endothelial cells was detected by differential display method. Some fragments that showed different expression level were picked up and were determined the primary sequence of these. From the results of database search, one of the fragments was identified as Leukemia-Associated Rho-GEF (LARG). From the open reading frame research, LARG of bovine endothelial cells was contained the specific domains of Dbl family. The homology each domain between bovine LARG and human LARG showed high as follows: 98.8 percent in PDZ domain, 95.7 percent in LH domain, 98.6 percent in DH domain and 99.2 percent in PH domain. In this study, the fragment that showed the different expression under clinorotation as LARG was identified. It was concluded that gravity vector changing affects the signaling pathway of Rho activation., 資料番号: AA0048095047},
 pages = {209--210},
 publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)},
 title = {血管内皮細胞における重力ベクトル変化に対するRho活性化因子の発現抑制とアミノ酸配列},
 year = {2005}
}