{"created":"2023-06-20T14:46:15.902754+00:00","id":13816,"links":{},"metadata":{"_buckets":{"deposit":"d3eb5452-49ff-4fe2-ad3f-bb2a5e3f4b3d"},"_deposit":{"created_by":1,"id":"13816","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13816"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013816","sets":["1543:1633:1647","1887:1891"]},"author_link":["126860","126857","126856","126859","126858","126855","126861","126854"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Effects of clinorotation on actin reformation in cells"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"30","bibliographicPageStart":"29","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第20回　平成15年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twentieth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Vector-altered gravity affects cytoskeletal formation. Actin stress fibers were disorganized under clinorotation, whereas the expression level of RhoA proteins, which stimulate the formation of actin stress fibers, was enhanced under that condition. From immunoblot analysis, the protein expression level of leukemia-associated Rho guanine nucleotide exchange factor (LARG), a kind of Rho-GEF, was depressed under clinorotation. And the gene expression level of LARG was also depressed under vector-averaged gravity. These results indicated that the depression of RhoA activation caused the disorganization of actin stress fiber, and Rho activation process might be affected by vector-averaged gravity. Signal transduction relating with Rho activation might be an important pathway of gravity sense and response mechanism on cells.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0046917011","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"宇宙航空研究開発機構 宇宙科学研究本部"},{"subitem_text_value":"エイ・イー・エス 宇宙開発部"},{"subitem_text_value":"エイ・イー・エス 宇宙開発部"},{"subitem_text_value":"宇宙航空研究開発機構 宇宙科学研究本部"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency Institute of Space and Astronautical Science"},{"subitem_text_language":"en","subitem_text_value":"Advanced Engineering Services Co. Ltd. Space Development Division"},{"subitem_text_language":"en","subitem_text_value":"Advanced Engineering Services Co. Ltd. Space Development Division"},{"subitem_text_language":"en","subitem_text_value":"Japan Aerospace Exploration Agency Institute of Space and Astronautical Science"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東端, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"関, 真也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤今溝, 真理"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石岡, 憲昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashibata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seki, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ImamizoSato, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishioka, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"クリノローテーション","subitem_subject_scheme":"Other"},{"subitem_subject":"アクチンストレスファイバー","subitem_subject_scheme":"Other"},{"subitem_subject":"蛍光顕微鏡","subitem_subject_scheme":"Other"},{"subitem_subject":"培養細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"活性化","subitem_subject_scheme":"Other"},{"subitem_subject":"重力効果","subitem_subject_scheme":"Other"},{"subitem_subject":"clinorotation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"actin stress fiber","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fluorescent microscope","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cultured cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"activation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gravitational effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"クリノスタット培養の細胞内アクチンファイバー再構成への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クリノスタット培養の細胞内アクチンファイバー再構成への影響"}]},"item_type_id":"5","owner":"1","path":["1647","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13816","relation_version_is_last":true,"title":["クリノスタット培養の細胞内アクチンファイバー再構成への影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:44:20.882839+00:00"}