@inproceedings{oai:jaxa.repo.nii.ac.jp:00013828, author = {野島, 久美恵 and 藤高, 和信 and 三谷, 弘明 and 樋野, 興夫 and Nojima, Kumie and Fujitaka, Kazunobu and Mitani, Hiroaki and Hino, Okio}, book = {宇宙利用シンポジウム 第20回 平成15年度, Space Utilization Research: Proceedings of the Twentieth Space Utilization Symposium}, month = {Mar}, note = {The Ekar rat model of hereditary renal carcinoma (RC) is an example of Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Effects of space radiation on carcinogenesis are investigated by using heavy-ions at HIMAC. First, analyzed was radio sensitivity of Ekar rats; compare the effects of heavy-ions (C-290 MeV/u, Fe-500 MeV/u) irradiation and X-ray irradiation. Pregnant rats were exposed to carbon-ion, iron-ion and X-ray at a single dose of 1 Gy, 2 Gy, 3 Gy on day 19 of gestation. The offspring were sacrificed at 8 weeks of age. RC developed in Ekar rats around the age of 8 weeks. The incidence of RC is investigated by comparing C-290 MeV/u, Fe-500 MeV/u and X-ray., 資料番号: AA0046917023}, pages = {70--71}, publisher = {宇宙航空研究開発機構宇宙科学研究本部, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)}, title = {重粒子線の発癌に及ぼす影響:ラット遺伝性腎癌}, year = {2004} }