{"created":"2023-06-20T14:46:16.762578+00:00","id":13829,"links":{},"metadata":{"_buckets":{"deposit":"33e95ef2-4c7d-4811-8c63-807e3a39efe2"},"_deposit":{"created_by":1,"id":"13829","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"13829"},"status":"published"},"_oai":{"id":"oai:jaxa.repo.nii.ac.jp:00013829","sets":["1543:1633:1647","1887:1891"]},"author_link":["126984","126982","126991","126988","126980","126986","126990","126985","126981","126987","126989","126983"],"item_5_alternative_title_2":{"attribute_name":"その他のタイトル（英）","attribute_value_mlt":[{"subitem_alternative_title":"Evaluation of the effect of space radiation on human organs and tissues maintained in SCID mice"}]},"item_5_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"73","bibliographicPageStart":"72","bibliographic_titles":[{"bibliographic_title":"宇宙利用シンポジウム　第20回　平成15年度"},{"bibliographic_title":"Space Utilization Research: Proceedings of the Twentieth Space Utilization Symposium","bibliographic_titleLang":"en"}]}]},"item_5_description_17":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"A Novel SCID technology is established for biomedical studies to evaluate the effect of space radiation on human organs and tissues. Morphology and function of human tissues were well maintained in the improved severe combined immunodeficient (SCID) mice for long period (2 to 3 years). Cs-137 ray exposure to transplant human thyroid tissues resulted in the disappearance of the follicles, significant decrease of human thyroid hormones, an increase of mutations, and change of gene expression, while low dose rate radiation exposure rarely induced these defects. Change of gene expression was also induced in extremely high incidence by fission neutron.","subitem_description_type":"Other"}]},"item_5_description_32":{"attribute_name":"資料番号","attribute_value_mlt":[{"subitem_description":"資料番号: AA0046917024","subitem_description_type":"Other"}]},"item_5_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宇宙航空研究開発機構宇宙科学研究本部"}]},"item_5_publisher_9":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_publisher":"Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)"}]},"item_5_text_6":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"大阪大学 大学院医学系研究科"},{"subitem_text_value":"大阪大学 大学院医学系研究科"},{"subitem_text_value":"大阪大学 大学院医学系研究科"},{"subitem_text_value":"大阪大学 大学院医学系研究科"},{"subitem_text_value":"大阪大学 大学院医学系研究科"},{"subitem_text_value":"大阪大学 大学院医学系研究科"}]},"item_5_text_7":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Osaka University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Osaka University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Osaka University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Osaka University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Osaka University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Osaka University Graduate School of Medicine"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野村, 大成"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中島, 裕夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本行, 忠志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梁, 治子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"足立, 成基"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"菊谷, 理絵"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Taisei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Hiroo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hongyo, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ryo, Haruko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuya, Rie","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト器官","subitem_subject_scheme":"Other"},{"subitem_subject":"宇宙放射線","subitem_subject_scheme":"Other"},{"subitem_subject":"形態学","subitem_subject_scheme":"Other"},{"subitem_subject":"甲状腺","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫不全","subitem_subject_scheme":"Other"},{"subitem_subject":"ホルモン","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human organ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"space radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"morphology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid gland","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunodeficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hormone","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"ヒト組織置換SCIDマウスを用いた宇宙放射線影響評価システムの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト組織置換SCIDマウスを用いた宇宙放射線影響評価システムの開発"}]},"item_type_id":"5","owner":"1","path":["1647","1891"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-26"},"publish_date":"2015-03-26","publish_status":"0","recid":"13829","relation_version_is_last":true,"title":["ヒト組織置換SCIDマウスを用いた宇宙放射線影響評価システムの開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-21T05:44:06.700971+00:00"}